Studies on methemoglobin and methemoglobin reductase in monkey erythrocytes during Plasmodium knowlesi infection

N. Saxena, S. K. Puri, S. K. Sahni, G. P. Dutta, V. C. Pandey

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Abstract

Plasmodium knowlesi infection in rhesus monkeys (Macaca mulatta) caused a decrease in the level of erythrocyte NAD-dependent met-hemoglobin reductase, the enzyme responsible for the conversion of met-hemoglobin to hemoglobin. The level of met-hemoglobin was thus increased whereas hemoglobin content was decreased as a result of malaria infection in the blood of monkeys. The activity of glucose-6-phosphate dehydrogenase, the enzyme mainly responsible for generation of NADPH, and the level of reduced glutathione were increased in P. knowlesi infected monkey erythrocytes.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalClinical Chemistry and Enzymology Communications
Volume2
Issue number1
StatePublished - Jan 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Biochemistry

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