Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling

Charles Ansong, Brooke L. Deatherage, Daniel Hyduke, Brian Schmidt, Jason E. McDermott, Marcus B. Jones, Sadhana Chauhan, Pep Charusanti, Young Mo Kim, Ernesto S. Nakayasu, Jie Li, Afshan Kidwai, George Niemann, Roslyn N. Brown, Thomas O. Metz, Kathleen McAteer, Fred Heffron, Scott N. Peterson, Vladimir Motin, Bernhard O. Palsson & 2 others Richard D. Smith, Joshua N. Adkins

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both outside of and within animal hosts. Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. These high-dimensional omics datasets are being integrated in selected ways to improve genome annotations, discover novel virulence-related factors, and model growth under infectious states. We will review the evolving technological approaches toward understanding complex microbial life through multi-omic measurements and integration, while highlighting some of our most recent successes in this area.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
Pages21-41
Number of pages21
Volume363
DOIs
StatePublished - 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume363
ISSN (Print)0070217X

Fingerprint

Host-Pathogen Interactions
Yersinia
Host Specificity
Salmonella
Metabolomics
Systems Biology
Virulence Factors
Proteomics
Life Style
Genome
Growth
Datasets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Ansong, C., Deatherage, B. L., Hyduke, D., Schmidt, B., McDermott, J. E., Jones, M. B., ... Adkins, J. N. (2012). Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. In Current Topics in Microbiology and Immunology (Vol. 363, pp. 21-41). (Current Topics in Microbiology and Immunology; Vol. 363). https://doi.org/10.1007/82-2012-247

Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. / Ansong, Charles; Deatherage, Brooke L.; Hyduke, Daniel; Schmidt, Brian; McDermott, Jason E.; Jones, Marcus B.; Chauhan, Sadhana; Charusanti, Pep; Kim, Young Mo; Nakayasu, Ernesto S.; Li, Jie; Kidwai, Afshan; Niemann, George; Brown, Roslyn N.; Metz, Thomas O.; McAteer, Kathleen; Heffron, Fred; Peterson, Scott N.; Motin, Vladimir; Palsson, Bernhard O.; Smith, Richard D.; Adkins, Joshua N.

Current Topics in Microbiology and Immunology. Vol. 363 2012. p. 21-41 (Current Topics in Microbiology and Immunology; Vol. 363).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ansong, C, Deatherage, BL, Hyduke, D, Schmidt, B, McDermott, JE, Jones, MB, Chauhan, S, Charusanti, P, Kim, YM, Nakayasu, ES, Li, J, Kidwai, A, Niemann, G, Brown, RN, Metz, TO, McAteer, K, Heffron, F, Peterson, SN, Motin, V, Palsson, BO, Smith, RD & Adkins, JN 2012, Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. in Current Topics in Microbiology and Immunology. vol. 363, Current Topics in Microbiology and Immunology, vol. 363, pp. 21-41. https://doi.org/10.1007/82-2012-247
Ansong C, Deatherage BL, Hyduke D, Schmidt B, McDermott JE, Jones MB et al. Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. In Current Topics in Microbiology and Immunology. Vol. 363. 2012. p. 21-41. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82-2012-247
Ansong, Charles ; Deatherage, Brooke L. ; Hyduke, Daniel ; Schmidt, Brian ; McDermott, Jason E. ; Jones, Marcus B. ; Chauhan, Sadhana ; Charusanti, Pep ; Kim, Young Mo ; Nakayasu, Ernesto S. ; Li, Jie ; Kidwai, Afshan ; Niemann, George ; Brown, Roslyn N. ; Metz, Thomas O. ; McAteer, Kathleen ; Heffron, Fred ; Peterson, Scott N. ; Motin, Vladimir ; Palsson, Bernhard O. ; Smith, Richard D. ; Adkins, Joshua N. / Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. Current Topics in Microbiology and Immunology. Vol. 363 2012. pp. 21-41 (Current Topics in Microbiology and Immunology).
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AU - Jones, Marcus B.

AU - Chauhan, Sadhana

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AU - Niemann, George

AU - Brown, Roslyn N.

AU - Metz, Thomas O.

AU - McAteer, Kathleen

AU - Heffron, Fred

AU - Peterson, Scott N.

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AU - Adkins, Joshua N.

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