Subareolar sentinel node biopsy for multiple breast cancers

Rakhshanda Layeeque, Ronda Henry-Tillman, Soheila Korourian, Rena Kass, Vicki Klimberg

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Sentinel lymph node biopsy (SLNB) is deemed suitable only for unifocal breast cancers since multiple foci of cancers may drain to different nodes. We hypothesized that subareolar injection (SI) could identify the sentinel lymph nodes (SLN) accurately in patients with multiple cancers (MC) in the breast. Methods: We prospectively employed SI of lymphazurin or technetium sulfur colloid, or both, for the identification of SLN in patients with MC in the breast. All patients underwent axillary dissection to compute the accuracy of SLNB. Results: Forty patients presented with MC in the same breast between January 1996 and July 2002. Fifty-two percent (21 of 40) of patients had involvement of more than 1 quadrant; 18% (7 of 40) had more than 1 histologic type of cancers. SLNs were successfully identified in 100% of patients. Axillary disease was present in 63% (25 of 40) of patients. Sensitivity of SLNB was 100% and false negative rate was 0%. The SLN was the only node involved in 45% (18 of 40) of patients. Conclusions: SLNB using the SI technique may be an alternative to complete axillary dissection in patients with multiple breast cancers.

Original languageEnglish (US)
Pages (from-to)730-736
Number of pages7
JournalAmerican Journal of Surgery
Volume186
Issue number6
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Breast Neoplasms
Biopsy
Sentinel Lymph Node Biopsy
Injections
Dissection
Technetium Tc 99m Sulfur Colloid
cyhalothrin
Neoplasms
Breast
Sentinel Lymph Node

Keywords

  • Multicentric breast cancer
  • Multifocal breast cancer
  • Sentinel lymph node biopsy
  • Subareolar injection

ASJC Scopus subject areas

  • Surgery

Cite this

Subareolar sentinel node biopsy for multiple breast cancers. / Layeeque, Rakhshanda; Henry-Tillman, Ronda; Korourian, Soheila; Kass, Rena; Klimberg, Vicki.

In: American Journal of Surgery, Vol. 186, No. 6, 2003, p. 730-736.

Research output: Contribution to journalArticle

Layeeque, Rakhshanda ; Henry-Tillman, Ronda ; Korourian, Soheila ; Kass, Rena ; Klimberg, Vicki. / Subareolar sentinel node biopsy for multiple breast cancers. In: American Journal of Surgery. 2003 ; Vol. 186, No. 6. pp. 730-736.
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