Abstract
Background: Sentinel lymph node biopsy (SLNB) is deemed suitable only for unifocal breast cancers since multiple foci of cancers may drain to different nodes. We hypothesized that subareolar injection (SI) could identify the sentinel lymph nodes (SLN) accurately in patients with multiple cancers (MC) in the breast. Methods: We prospectively employed SI of lymphazurin or technetium sulfur colloid, or both, for the identification of SLN in patients with MC in the breast. All patients underwent axillary dissection to compute the accuracy of SLNB. Results: Forty patients presented with MC in the same breast between January 1996 and July 2002. Fifty-two percent (21 of 40) of patients had involvement of more than 1 quadrant; 18% (7 of 40) had more than 1 histologic type of cancers. SLNs were successfully identified in 100% of patients. Axillary disease was present in 63% (25 of 40) of patients. Sensitivity of SLNB was 100% and false negative rate was 0%. The SLN was the only node involved in 45% (18 of 40) of patients. Conclusions: SLNB using the SI technique may be an alternative to complete axillary dissection in patients with multiple breast cancers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 730-736 |
| Number of pages | 7 |
| Journal | American Journal of Surgery |
| Volume | 186 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2003 |
| Externally published | Yes |
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Keywords
- Multicentric breast cancer
- Multifocal breast cancer
- Sentinel lymph node biopsy
- Subareolar injection
ASJC Scopus subject areas
- Surgery
Cite this
Subareolar sentinel node biopsy for multiple breast cancers. / Layeeque, Rakhshanda; Henry-Tillman, Ronda; Korourian, Soheila; Kass, Rena; Klimberg, Vicki.
In: American Journal of Surgery, Vol. 186, No. 6, 2003, p. 730-736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subareolar sentinel node biopsy for multiple breast cancers
AU - Layeeque, Rakhshanda
AU - Henry-Tillman, Ronda
AU - Korourian, Soheila
AU - Kass, Rena
AU - Klimberg, Vicki
PY - 2003
Y1 - 2003
N2 - Background: Sentinel lymph node biopsy (SLNB) is deemed suitable only for unifocal breast cancers since multiple foci of cancers may drain to different nodes. We hypothesized that subareolar injection (SI) could identify the sentinel lymph nodes (SLN) accurately in patients with multiple cancers (MC) in the breast. Methods: We prospectively employed SI of lymphazurin or technetium sulfur colloid, or both, for the identification of SLN in patients with MC in the breast. All patients underwent axillary dissection to compute the accuracy of SLNB. Results: Forty patients presented with MC in the same breast between January 1996 and July 2002. Fifty-two percent (21 of 40) of patients had involvement of more than 1 quadrant; 18% (7 of 40) had more than 1 histologic type of cancers. SLNs were successfully identified in 100% of patients. Axillary disease was present in 63% (25 of 40) of patients. Sensitivity of SLNB was 100% and false negative rate was 0%. The SLN was the only node involved in 45% (18 of 40) of patients. Conclusions: SLNB using the SI technique may be an alternative to complete axillary dissection in patients with multiple breast cancers.
AB - Background: Sentinel lymph node biopsy (SLNB) is deemed suitable only for unifocal breast cancers since multiple foci of cancers may drain to different nodes. We hypothesized that subareolar injection (SI) could identify the sentinel lymph nodes (SLN) accurately in patients with multiple cancers (MC) in the breast. Methods: We prospectively employed SI of lymphazurin or technetium sulfur colloid, or both, for the identification of SLN in patients with MC in the breast. All patients underwent axillary dissection to compute the accuracy of SLNB. Results: Forty patients presented with MC in the same breast between January 1996 and July 2002. Fifty-two percent (21 of 40) of patients had involvement of more than 1 quadrant; 18% (7 of 40) had more than 1 histologic type of cancers. SLNs were successfully identified in 100% of patients. Axillary disease was present in 63% (25 of 40) of patients. Sensitivity of SLNB was 100% and false negative rate was 0%. The SLN was the only node involved in 45% (18 of 40) of patients. Conclusions: SLNB using the SI technique may be an alternative to complete axillary dissection in patients with multiple breast cancers.
KW - Multicentric breast cancer
KW - Multifocal breast cancer
KW - Sentinel lymph node biopsy
KW - Subareolar injection
UR - http://www.scopus.com/inward/record.url?scp=0348111561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0348111561&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2003.08.014
DO - 10.1016/j.amjsurg.2003.08.014
M3 - Article
C2 - 14672787
AN - SCOPUS:0348111561
VL - 186
SP - 730
EP - 736
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 6
ER -