Substance abuse increases the risk of neuropathy in an HIV-infected cohort.

Jessica Robinson-Papp, Benjamin Gelman, Igor Grant, Elyse Singer, Gary Gensler, Susan Morgello, NeuroAIDS Tissue Consortium National NeuroAIDS Tissue Consortium

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21 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV)-infected patients commonly develop distal symmetric polyneuropathy (DSP). Age, ethnicity, and toxic exposures may influence the risk. In this study we examined the association between substance use, antiretrovirals, ethnicity, and incident neuropathy in an HIV-infected cohort. Data were obtained from the National NeuroAIDS Tissue Consortium (NNTC), an ongoing, prospective cohort started in 1998. Cox proportional hazards models were used to examine the association of substance use, demographics, neurotoxic antiretrovirals, and laboratory parameters with incident neuropathy in 636 participants who were neuropathy-free at baseline. The cumulative incidence of DSP was 41%. Substance use (P = 0.04), number of substances used (P = 0.04), and longer duration of HIV infection (P = 0.05) were associated with incident DSP, but demographic factors, use of neurotoxic antiretrovirals, and laboratory parameters were not. Substance use and longer duration of HIV infection are risk factors for DSP in HIV-infected patients. Use of multiple substances may be particularly risky.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
JournalMuscle & Nerve
Volume45
Issue number4
DOIs
StatePublished - Apr 2012

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Polyneuropathies
Substance-Related Disorders
HIV
Virus Diseases
Substance P
Demography
Poisons
Proportional Hazards Models
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Robinson-Papp, J., Gelman, B., Grant, I., Singer, E., Gensler, G., Morgello, S., & National NeuroAIDS Tissue Consortium, NIDS. T. C. (2012). Substance abuse increases the risk of neuropathy in an HIV-infected cohort. Muscle & Nerve, 45(4), 471-476. https://doi.org/10.1002/mus.23231

Substance abuse increases the risk of neuropathy in an HIV-infected cohort. / Robinson-Papp, Jessica; Gelman, Benjamin; Grant, Igor; Singer, Elyse; Gensler, Gary; Morgello, Susan; National NeuroAIDS Tissue Consortium, NeuroAIDS Tissue Consortium.

In: Muscle & Nerve, Vol. 45, No. 4, 04.2012, p. 471-476.

Research output: Contribution to journalArticle

Robinson-Papp, J, Gelman, B, Grant, I, Singer, E, Gensler, G, Morgello, S & National NeuroAIDS Tissue Consortium, NIDSTC 2012, 'Substance abuse increases the risk of neuropathy in an HIV-infected cohort.', Muscle & Nerve, vol. 45, no. 4, pp. 471-476. https://doi.org/10.1002/mus.23231
Robinson-Papp J, Gelman B, Grant I, Singer E, Gensler G, Morgello S et al. Substance abuse increases the risk of neuropathy in an HIV-infected cohort. Muscle & Nerve. 2012 Apr;45(4):471-476. https://doi.org/10.1002/mus.23231
Robinson-Papp, Jessica ; Gelman, Benjamin ; Grant, Igor ; Singer, Elyse ; Gensler, Gary ; Morgello, Susan ; National NeuroAIDS Tissue Consortium, NeuroAIDS Tissue Consortium. / Substance abuse increases the risk of neuropathy in an HIV-infected cohort. In: Muscle & Nerve. 2012 ; Vol. 45, No. 4. pp. 471-476.
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