Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways

Grégory Giannone, Michael Sheetz

Research output: Contribution to journalReview article

212 Scopus citations

Abstract

Cell forces define cell morphology, alterations in which are caused by tyrosine kinase and phosphatase mutations, which implies a causal linkage. Recent studies have shown that phosphotyrosine signaling is involved in force sensing for cells on flat surfaces. Early force-dependent activation of Src family kinases by phosphatases or cytoskeleton stretch leads to the activation of downstream signaling. In addition, force generation by cells depends on a feedback mechanism between matrix rigidity or force generation and myosin contractility. Components of the force-sensing pathway are linked to the integrin-cytoskeleton complex at sites of force application and serve as scaffolds for signaling processes. Thus, early events in force detection are mechanically induced cytoskeletal changes that result in biochemical signals to mechanoresponsive pathways that then regulate cell form.

Original languageEnglish (US)
Pages (from-to)213-223
Number of pages11
JournalTrends in Cell Biology
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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