Abstract
Cell forces define cell morphology, alterations in which are caused by tyrosine kinase and phosphatase mutations, which implies a causal linkage. Recent studies have shown that phosphotyrosine signaling is involved in force sensing for cells on flat surfaces. Early force-dependent activation of Src family kinases by phosphatases or cytoskeleton stretch leads to the activation of downstream signaling. In addition, force generation by cells depends on a feedback mechanism between matrix rigidity or force generation and myosin contractility. Components of the force-sensing pathway are linked to the integrin-cytoskeleton complex at sites of force application and serve as scaffolds for signaling processes. Thus, early events in force detection are mechanically induced cytoskeletal changes that result in biochemical signals to mechanoresponsive pathways that then regulate cell form.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-223 |
| Number of pages | 11 |
| Journal | Trends in Cell Biology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. / Giannone, Grégory; Sheetz, Michael.
In: Trends in Cell Biology, Vol. 16, No. 4, 01.04.2006, p. 213-223.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways
AU - Giannone, Grégory
AU - Sheetz, Michael
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Cell forces define cell morphology, alterations in which are caused by tyrosine kinase and phosphatase mutations, which implies a causal linkage. Recent studies have shown that phosphotyrosine signaling is involved in force sensing for cells on flat surfaces. Early force-dependent activation of Src family kinases by phosphatases or cytoskeleton stretch leads to the activation of downstream signaling. In addition, force generation by cells depends on a feedback mechanism between matrix rigidity or force generation and myosin contractility. Components of the force-sensing pathway are linked to the integrin-cytoskeleton complex at sites of force application and serve as scaffolds for signaling processes. Thus, early events in force detection are mechanically induced cytoskeletal changes that result in biochemical signals to mechanoresponsive pathways that then regulate cell form.
AB - Cell forces define cell morphology, alterations in which are caused by tyrosine kinase and phosphatase mutations, which implies a causal linkage. Recent studies have shown that phosphotyrosine signaling is involved in force sensing for cells on flat surfaces. Early force-dependent activation of Src family kinases by phosphatases or cytoskeleton stretch leads to the activation of downstream signaling. In addition, force generation by cells depends on a feedback mechanism between matrix rigidity or force generation and myosin contractility. Components of the force-sensing pathway are linked to the integrin-cytoskeleton complex at sites of force application and serve as scaffolds for signaling processes. Thus, early events in force detection are mechanically induced cytoskeletal changes that result in biochemical signals to mechanoresponsive pathways that then regulate cell form.
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UR - http://www.scopus.com/inward/citedby.url?scp=33645889655&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2006.02.005
DO - 10.1016/j.tcb.2006.02.005
M3 - Review article
VL - 16
SP - 213
EP - 223
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 4
ER -