Substrate specificity and screening of the integral membrane protease Pla

Anton Agarkov, Sadhana Chauhan, Pedro J. Lory, Scott R. Gilbertson, Vladimir L. Motin

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

This paper reports a study to find small peptide substrates for the important virulence factor of Yersinia pestis, plasminogen activator, Pla. The method used to find small substrates for this protease is reported along with studies examining the ability of these peptides to inhibit activity of the enzyme. Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2008

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Keywords

  • Parallel synthesis
  • Peptide inhibitor
  • Plasminogen activator
  • Positional scan
  • Protease substrate
  • Yersinia pestis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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