Substrate specificity and screening of the integral membrane protease Pla

Anton Agarkov, Sadhana Chauhan, Pedro J. Lory, Scott R. Gilbertson, Vladimir Motin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This paper reports a study to find small peptide substrates for the important virulence factor of Yersinia pestis, plasminogen activator, Pla. The method used to find small substrates for this protease is reported along with studies examining the ability of these peptides to inhibit activity of the enzyme. Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Substrate Specificity
Screening
Peptide Hydrolases
Membranes
Yersinia pestis
Peptides
Plasminogen Activators
Virulence Factors
Substrates
Enzymes
Scanning

Keywords

  • Parallel synthesis
  • Peptide inhibitor
  • Plasminogen activator
  • Positional scan
  • Protease substrate
  • Yersinia pestis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Substrate specificity and screening of the integral membrane protease Pla. / Agarkov, Anton; Chauhan, Sadhana; Lory, Pedro J.; Gilbertson, Scott R.; Motin, Vladimir.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 1, 01.01.2008, p. 427-431.

Research output: Contribution to journalArticle

Agarkov, Anton ; Chauhan, Sadhana ; Lory, Pedro J. ; Gilbertson, Scott R. ; Motin, Vladimir. / Substrate specificity and screening of the integral membrane protease Pla. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 1. pp. 427-431.
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