Successful intracerebroventricular allotransplantation of parathyroid tissue in rats without immunosuppression

Zheng Yao Chong Zheng Yao, J. Ishizuka, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The lateral ventricle of the brain may be an immunoprivileged site for viable allografts. Allotransplanted parathyroid tissue from histoincompatible ACI rats survived and remained functional for more than 3 months in the cerebroventricles of recipient F344 rats. Microscopic examination proved that the allotransplanted parathyroid tissues retained normal histological features. In sharp contrast, when the parathyroid was placed beneath the renal capsule the allografted parathyroid tissue uniformly lost its capacity to liberate parathyroid hormone within one month, and only residual scar tissue remained at the transplantation site. After allotransplantation of parathyroid tissue into the cerebroventricle, the serum concentrations of both Ca++ and parathyroid hormone were maintained at levels similar to those before parathyroidectomy, until the time of sacrifice. During the 3- month period of posttransplantation observation, no neurological symptoms were noted in any of the F344 rats.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalTransplantation
Volume55
Issue number2
StatePublished - 1993

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Immunosuppression
Inbred F344 Rats
Parathyroid Hormone
Inbred ACI Rats
Parathyroidectomy
Lateral Ventricles
Capsules
Cicatrix
Allografts
Transplantation
Observation
Kidney
Brain
Serum

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Successful intracerebroventricular allotransplantation of parathyroid tissue in rats without immunosuppression. / Chong Zheng Yao, Zheng Yao; Ishizuka, J.; Townsend, Courtney; Thompson, J. C.

In: Transplantation, Vol. 55, No. 2, 1993, p. 251-253.

Research output: Contribution to journalArticle

Chong Zheng Yao, Zheng Yao ; Ishizuka, J. ; Townsend, Courtney ; Thompson, J. C. / Successful intracerebroventricular allotransplantation of parathyroid tissue in rats without immunosuppression. In: Transplantation. 1993 ; Vol. 55, No. 2. pp. 251-253.
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