Successful treatment of aortic root abscess in a patient with pulmonary arterial hypertension

Amitesh Agarwal, Andras Kollar, Alexander G. Duarte

Research output: Contribution to journalArticlepeer-review


Continuous prostanoid infusion is an established treatment for pulmonary arterial hypertension that has led to improvements in symptoms, exercise tolerance, and survival. Patients with pulmonary arterial hypertension (PAH) who develop sepsis frequently experience clinical and hemodynamic deterioration associated with poor outcomes. Successful management of sepsis involves identification of the source of infection, early antimicrobial administration, judicious fluid resuscitation, and continuation of specific PAH therapies. We describe successful management of a patient with idiopathic PAH receiving chronic intravenous prostacyclin therapy who developed an aortic root abscess due to Clostridium perfringens requiring emergent aortic root repair. Management involved imaging studies, removalof potential sources with administration of intravenous antibiotics, and cautious fluid administration with hemodynamic monitoring. A multidisciplinary group led by a PAH specialist worked cohesively before, during, and after surgical intervention and achieved a successful outcome.

Original languageEnglish (US)
Pages (from-to)726-729
Number of pages4
JournalPulmonary Circulation
Issue number4
StatePublished - Oct 26 2015


  • Clostridium perfringens
  • Infective endocarditis
  • Perioperative management
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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