Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone

Jafar Farnam; J. Andrew Grant; Brock G. Guernsey; Joseph L. Jorizzo; Emil R. Petrusa

doi:10.1016/0091-6749(84)90457-3

Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone

Jafar Farnam, J. Andrew Grant, Brock G. Guernsey, Joseph L. Jorizzo, Emil R. Petrusa

Internal Medicine

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H₂- rather than H₁-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.

Original language	English (US)
Pages (from-to)	842-845
Number of pages	4
Journal	The Journal of Allergy and Clinical Immunology
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/0091-6749(84)90457-3
State	Published - Jun 1984

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ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

Farnam, J., Grant, J. A., Guernsey, B. G., Jorizzo, J. L., & Petrusa, E. R. (1984). Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. The Journal of Allergy and Clinical Immunology, 73(6), 842-845. https://doi.org/10.1016/0091-6749(84)90457-3

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abstract = "We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.",

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10.1016/0091-6749(84)90457-3