Abstract
We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 842-845 |
| Number of pages | 4 |
| Journal | The Journal of Allergy and Clinical Immunology |
| Volume | 73 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1984 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. / Farnam, Jafar; Grant, J. Andrew; Guernsey, Brock G.; Jorizzo, Joseph L.; Petrusa, Emil R.
In: The Journal of Allergy and Clinical Immunology, Vol. 73, No. 6, 1984, p. 842-845.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone
AU - Farnam, Jafar
AU - Grant, J. Andrew
AU - Guernsey, Brock G.
AU - Jorizzo, Joseph L.
AU - Petrusa, Emil R.
PY - 1984
Y1 - 1984
N2 - We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.
AB - We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021180193&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(84)90457-3
DO - 10.1016/0091-6749(84)90457-3
M3 - Article
VL - 73
SP - 842
EP - 845
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 6
ER -