Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone

Jafar Farnam, J. Andrew Grant, Brock G. Guernsey, Joseph L. Jorizzo, Emil R. Petrusa

Research output: Contribution to journalArticle

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Abstract

We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.

Original languageEnglish (US)
Pages (from-to)842-845
Number of pages4
JournalThe Journal of Allergy and Clinical Immunology
Volume73
Issue number6
DOIs
StatePublished - Jun 1984

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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