Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone

Jafar Farnam; J. Andrew Grant; Brock G. Guernsey; Joseph L. Jorizzo; Emil R. Petrusa

doi:10.1016/0091-6749(84)90457-3

Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone

Jafar Farnam
, J. Andrew Grant
, Brock G. Guernsey
, Joseph L. Jorizzo
, Emil R. Petrusa

Internal Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H₂- rather than H₁-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.

Original language	English (US)
Pages (from-to)	842-845
Number of pages	4
Journal	The Journal of Allergy and Clinical Immunology
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/0091-6749(84)90457-3
State	Published - Jun 1984

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone",

abstract = "We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.",

author = "Jafar Farnam and Grant, \{J. Andrew\} and Guernsey, \{Brock G.\} and Jorizzo, \{Joseph L.\} and Petrusa, \{Emil R.\}",

note = "Funding Information: From the University of Texas Medical Branch, Departments of Internal Medicine and Dermatology, Galveston, Texas. Supported in part by National Institutes of Health grant AI-12621 and by the James P. McLaughlin Fellowship Fund (Dr. Fantarn). Received for publication Nov. 1, 1983. Accepted for publication Feb. 20, 1984. Reprint requests: J\&u Farnam, M.D., Division of Adult Allergy, Department of Internal Medicine, Clinical Seienees 409, Uni-versity of Texas Medical Branch, Galveston, TX 77550.",

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doi = "10.1016/0091-6749(84)90457-3",

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AU - Grant, J. Andrew

AU - Guernsey, Brock G.

AU - Jorizzo, Joseph L.

AU - Petrusa, Emil R.

N1 - Funding Information: From the University of Texas Medical Branch, Departments of Internal Medicine and Dermatology, Galveston, Texas. Supported in part by National Institutes of Health grant AI-12621 and by the James P. McLaughlin Fellowship Fund (Dr. Fantarn). Received for publication Nov. 1, 1983. Accepted for publication Feb. 20, 1984. Reprint requests: J&u Farnam, M.D., Division of Adult Allergy, Department of Internal Medicine, Clinical Seienees 409, Uni-versity of Texas Medical Branch, Galveston, TX 77550.

PY - 1984/6

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N2 - We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.

AB - We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p < 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p < 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.

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Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone

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