Successful urokinase treatment of massive pulmonary embolism in pregnancy

Wayne B. Kramer, Michael Belfort, George Saade, Salim Surani, Kenneth J. Moise

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Thrombolytic agents have been used successfully to treat patients with massive pulmonary embolism and cardiorespiratory insufficiency, but experience with these drugs in pregnancy is limited. Case: A 20-year-old woman at 21 weeks' gestation was admitted with a massive pulmonary embolism. She was initially given intravenous heparin therapy but because of worsening clinical condition, urokinase was used. After two 12-hour periods of therapy, the urokinase was discontinued and the heparin restarted. She remained on subcutaneous heparin therapy for the remainder of her pregnancy, which was otherwise uncomplicated. She delivered a healthy male infant at term without complications and was discharged on warfarin therapy. Conclusion: Thrombolytic therapy can be life-saving and should be considered in the treatment of hemodynamicaily significant pulmonary embolism in pregnancy.

Original languageEnglish (US)
Pages (from-to)660-662
Number of pages3
JournalObstetrics and Gynecology
Volume86
Issue number4 PART 2
DOIs
StatePublished - 1995
Externally publishedYes

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Urokinase-Type Plasminogen Activator
Pulmonary Embolism
Pregnancy
Heparin
Therapeutics
Fibrinolytic Agents
Thrombolytic Therapy
Warfarin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Successful urokinase treatment of massive pulmonary embolism in pregnancy. / Kramer, Wayne B.; Belfort, Michael; Saade, George; Surani, Salim; Moise, Kenneth J.

In: Obstetrics and Gynecology, Vol. 86, No. 4 PART 2, 1995, p. 660-662.

Research output: Contribution to journalArticle

Kramer, Wayne B. ; Belfort, Michael ; Saade, George ; Surani, Salim ; Moise, Kenneth J. / Successful urokinase treatment of massive pulmonary embolism in pregnancy. In: Obstetrics and Gynecology. 1995 ; Vol. 86, No. 4 PART 2. pp. 660-662.
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