Abstract
Abstract: The subcellular distributions of the enzymes associated with the methylation and cystathionine‐synthesizing portion of the sulfur amino acid metabolic pathway have been determined in the occipital lobe of the rhesus monkey. 5‐Methyltetrahydrofolate‐homocysteine methyltransferase and 5, 10‐methylenetetrahydrofolate reductase activities are located mainly in the soluble compartment. Serine hydroxymethyltransferase activity is located primarily in mitochondria. Cystathionine β‐synthase is a soluble enzyme with a significant component occluded within the nerve endings. Glycine, serine, and cystathionine increase per gram of tissue during development. Glycine and serine are approximately 30% occluded within the nerve endings. These data are consistent with a localization of sulfur amino acid metabolism that supports a differential compartmentation of potential neurotransmitter function and methylation function in the primate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1263-1271 |
| Number of pages | 9 |
| Journal | Journal of neurochemistry |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1981 |
| Externally published | Yes |
Keywords
- Cystathionine
- Methylation cycle
- Methylenetetrahydrofolate reductase
- Methyltetrahydrofolate homocysteine methyltransferase
- Serine hydroxymethyltransferase
- cystathionine synthase
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience