Sulfur Amino Acid Metabolism in the Developing Rhesus Monkey Brain: Subcellular Studies of the Methylation Cycle and Cystathionine β‐Synthase

David K. Rassin, John A. Sturman, Gerald E. Gaull

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Abstract: The subcellular distributions of the enzymes associated with the methylation and cystathionine‐synthesizing portion of the sulfur amino acid metabolic pathway have been determined in the occipital lobe of the rhesus monkey. 5‐Methyltetrahydrofolate‐homocysteine methyltransferase and 5, 10‐methylenetetrahydrofolate reductase activities are located mainly in the soluble compartment. Serine hydroxymethyltransferase activity is located primarily in mitochondria. Cystathionine β‐synthase is a soluble enzyme with a significant component occluded within the nerve endings. Glycine, serine, and cystathionine increase per gram of tissue during development. Glycine and serine are approximately 30% occluded within the nerve endings. These data are consistent with a localization of sulfur amino acid metabolism that supports a differential compartmentation of potential neurotransmitter function and methylation function in the primate.

Original languageEnglish (US)
Pages (from-to)1263-1271
Number of pages9
JournalJournal of neurochemistry
Volume36
Issue number3
DOIs
StatePublished - Mar 1981

Keywords

  • Cystathionine
  • Methylation cycle
  • Methylenetetrahydrofolate reductase
  • Methyltetrahydrofolate homocysteine methyltransferase
  • Serine hydroxymethyltransferase
  • cystathionine synthase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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