Sulfur amino acid metabolism in the developing rhesus monkey brain

Interrelationship of taurine and glutamate

David K. Rassin, John A. Sturman, Gerald E. Gaull

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The relationship of taurine to glutamate, and to other amino acids, has been examined in the occipital lobe of the developing rhesus monkey. During development taurine decreases in concentration (4.96 μmol/g in fetus to 1.52 μmol/g in adult) while glutamate increases (7.92 μmol/g in fetus to 11.26 μmol/g in adult). When the concentration of taurine is plotted against that of glutamate in fetal, neonatal and adult animals there is a significant correlation in the fetal (p<0.01) and adult (p<0.01) but not in the neonatal occipital lobe samples. This correlation in both fetal and adult brain is specific for these two amino acids. Subcellular fractionation studies further indicate that this relationship may be of special importance in nerve endings.

Original languageEnglish (US)
Pages (from-to)1107-1118
Number of pages12
JournalNeurochemical Research
Volume7
Issue number9
DOIs
StatePublished - Sep 1982
Externally publishedYes

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Sulfur Amino Acids
Taurine
Macaca mulatta
Metabolism
Glutamic Acid
Occipital Lobe
Brain
Fetus
Newborn Animals
Amino Acids
Nerve Endings
Fractionation
Animals

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Sulfur amino acid metabolism in the developing rhesus monkey brain : Interrelationship of taurine and glutamate. / Rassin, David K.; Sturman, John A.; Gaull, Gerald E.

In: Neurochemical Research, Vol. 7, No. 9, 09.1982, p. 1107-1118.

Research output: Contribution to journalArticle

Rassin, David K. ; Sturman, John A. ; Gaull, Gerald E. / Sulfur amino acid metabolism in the developing rhesus monkey brain : Interrelationship of taurine and glutamate. In: Neurochemical Research. 1982 ; Vol. 7, No. 9. pp. 1107-1118.
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