Summary Points and Consensus Recommendations from the International Protein Summit

Ryan T. Hurt, Stephen A. McClave, Robert G. Martindale, Juan B. Ochoa Gautier, Jorge A. Coss-Bu, Roland N. Dickerson, Daren K. Heyland, L. John Hoffer, Frederick A. Moore, Claudia R. Morris, Douglas Paddon-Jones, Jayshil J. Patel, Stuart M. Phillips, Saúl J. Rugeles, Menaka Sarav, Peter J.M. Weijs, Jan Wernerman, Jill Hamilton-Reeves, Craig J. McClain, Beth Taylor

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been suggested that high doses of protein in the range of 1.2-2.5 g/kg/d may be required in the setting of the intensive care unit (ICU) to optimize nutrition therapy and reduce mortality. While incapable of blunting the catabolic response, protein doses in this range may be needed to best stimulate new protein synthesis and preserve muscle mass. Quality of protein (determined by source, content and ratio of amino acids, and digestibility) affects nutrient sensing pathways such as the mammalian target of rapamycin. Achieving protein goals the first week following admission to the ICU should take precedence over meeting energy goals. High-protein hypocaloric (providing 80%-90% of caloric requirements) feeding may evolve as the best strategy during the initial phase of critical illness to avoid overfeeding, improve insulin sensitivity, and maintain body protein homeostasis, especially in the patient at high nutrition risk. This article provides a set of recommendations based on assessment of the current literature to guide healthcare professionals in clinical practice at this time, as well as a list of potential topics to guide investigators for purposes of research in the future.

Original languageEnglish (US)
Pages (from-to)142S-151S
JournalNutrition in Clinical Practice
Volume32
Issue number1_suppl
DOIs
StatePublished - Apr 1 2017

Fingerprint

Proteins
Critical Illness
Intensive Care Units
Nutrition Therapy
Sirolimus
Insulin Resistance
Homeostasis
Research Personnel
Delivery of Health Care
Amino Acids
Food
Muscles
Mortality
Research

Keywords

  • amino acids
  • enteral nutrition
  • lean body mass
  • parenteral nutrition
  • protein

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Hurt, R. T., McClave, S. A., Martindale, R. G., Ochoa Gautier, J. B., Coss-Bu, J. A., Dickerson, R. N., ... Taylor, B. (2017). Summary Points and Consensus Recommendations from the International Protein Summit. Nutrition in Clinical Practice, 32(1_suppl), 142S-151S. https://doi.org/10.1177/0884533617693610

Summary Points and Consensus Recommendations from the International Protein Summit. / Hurt, Ryan T.; McClave, Stephen A.; Martindale, Robert G.; Ochoa Gautier, Juan B.; Coss-Bu, Jorge A.; Dickerson, Roland N.; Heyland, Daren K.; Hoffer, L. John; Moore, Frederick A.; Morris, Claudia R.; Paddon-Jones, Douglas; Patel, Jayshil J.; Phillips, Stuart M.; Rugeles, Saúl J.; Sarav, Menaka; Weijs, Peter J.M.; Wernerman, Jan; Hamilton-Reeves, Jill; McClain, Craig J.; Taylor, Beth.

In: Nutrition in Clinical Practice, Vol. 32, No. 1_suppl, 01.04.2017, p. 142S-151S.

Research output: Contribution to journalArticle

Hurt, RT, McClave, SA, Martindale, RG, Ochoa Gautier, JB, Coss-Bu, JA, Dickerson, RN, Heyland, DK, Hoffer, LJ, Moore, FA, Morris, CR, Paddon-Jones, D, Patel, JJ, Phillips, SM, Rugeles, SJ, Sarav, M, Weijs, PJM, Wernerman, J, Hamilton-Reeves, J, McClain, CJ & Taylor, B 2017, 'Summary Points and Consensus Recommendations from the International Protein Summit', Nutrition in Clinical Practice, vol. 32, no. 1_suppl, pp. 142S-151S. https://doi.org/10.1177/0884533617693610
Hurt RT, McClave SA, Martindale RG, Ochoa Gautier JB, Coss-Bu JA, Dickerson RN et al. Summary Points and Consensus Recommendations from the International Protein Summit. Nutrition in Clinical Practice. 2017 Apr 1;32(1_suppl):142S-151S. https://doi.org/10.1177/0884533617693610
Hurt, Ryan T. ; McClave, Stephen A. ; Martindale, Robert G. ; Ochoa Gautier, Juan B. ; Coss-Bu, Jorge A. ; Dickerson, Roland N. ; Heyland, Daren K. ; Hoffer, L. John ; Moore, Frederick A. ; Morris, Claudia R. ; Paddon-Jones, Douglas ; Patel, Jayshil J. ; Phillips, Stuart M. ; Rugeles, Saúl J. ; Sarav, Menaka ; Weijs, Peter J.M. ; Wernerman, Jan ; Hamilton-Reeves, Jill ; McClain, Craig J. ; Taylor, Beth. / Summary Points and Consensus Recommendations from the International Protein Summit. In: Nutrition in Clinical Practice. 2017 ; Vol. 32, No. 1_suppl. pp. 142S-151S.
@article{b0ae14f68300475fa140eeca309b573f,
title = "Summary Points and Consensus Recommendations from the International Protein Summit",
abstract = "The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been suggested that high doses of protein in the range of 1.2-2.5 g/kg/d may be required in the setting of the intensive care unit (ICU) to optimize nutrition therapy and reduce mortality. While incapable of blunting the catabolic response, protein doses in this range may be needed to best stimulate new protein synthesis and preserve muscle mass. Quality of protein (determined by source, content and ratio of amino acids, and digestibility) affects nutrient sensing pathways such as the mammalian target of rapamycin. Achieving protein goals the first week following admission to the ICU should take precedence over meeting energy goals. High-protein hypocaloric (providing 80{\%}-90{\%} of caloric requirements) feeding may evolve as the best strategy during the initial phase of critical illness to avoid overfeeding, improve insulin sensitivity, and maintain body protein homeostasis, especially in the patient at high nutrition risk. This article provides a set of recommendations based on assessment of the current literature to guide healthcare professionals in clinical practice at this time, as well as a list of potential topics to guide investigators for purposes of research in the future.",
keywords = "amino acids, enteral nutrition, lean body mass, parenteral nutrition, protein",
author = "Hurt, {Ryan T.} and McClave, {Stephen A.} and Martindale, {Robert G.} and {Ochoa Gautier}, {Juan B.} and Coss-Bu, {Jorge A.} and Dickerson, {Roland N.} and Heyland, {Daren K.} and Hoffer, {L. John} and Moore, {Frederick A.} and Morris, {Claudia R.} and Douglas Paddon-Jones and Patel, {Jayshil J.} and Phillips, {Stuart M.} and Rugeles, {Sa{\'u}l J.} and Menaka Sarav and Weijs, {Peter J.M.} and Jan Wernerman and Jill Hamilton-Reeves and McClain, {Craig J.} and Beth Taylor",
year = "2017",
month = "4",
day = "1",
doi = "10.1177/0884533617693610",
language = "English (US)",
volume = "32",
pages = "142S--151S",
journal = "Nutrition in Clinical Practice",
issn = "0884-5336",
publisher = "SAGE Publications Ltd",
number = "1_suppl",

}

TY - JOUR

T1 - Summary Points and Consensus Recommendations from the International Protein Summit

AU - Hurt, Ryan T.

AU - McClave, Stephen A.

AU - Martindale, Robert G.

AU - Ochoa Gautier, Juan B.

AU - Coss-Bu, Jorge A.

AU - Dickerson, Roland N.

AU - Heyland, Daren K.

AU - Hoffer, L. John

AU - Moore, Frederick A.

AU - Morris, Claudia R.

AU - Paddon-Jones, Douglas

AU - Patel, Jayshil J.

AU - Phillips, Stuart M.

AU - Rugeles, Saúl J.

AU - Sarav, Menaka

AU - Weijs, Peter J.M.

AU - Wernerman, Jan

AU - Hamilton-Reeves, Jill

AU - McClain, Craig J.

AU - Taylor, Beth

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been suggested that high doses of protein in the range of 1.2-2.5 g/kg/d may be required in the setting of the intensive care unit (ICU) to optimize nutrition therapy and reduce mortality. While incapable of blunting the catabolic response, protein doses in this range may be needed to best stimulate new protein synthesis and preserve muscle mass. Quality of protein (determined by source, content and ratio of amino acids, and digestibility) affects nutrient sensing pathways such as the mammalian target of rapamycin. Achieving protein goals the first week following admission to the ICU should take precedence over meeting energy goals. High-protein hypocaloric (providing 80%-90% of caloric requirements) feeding may evolve as the best strategy during the initial phase of critical illness to avoid overfeeding, improve insulin sensitivity, and maintain body protein homeostasis, especially in the patient at high nutrition risk. This article provides a set of recommendations based on assessment of the current literature to guide healthcare professionals in clinical practice at this time, as well as a list of potential topics to guide investigators for purposes of research in the future.

AB - The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been suggested that high doses of protein in the range of 1.2-2.5 g/kg/d may be required in the setting of the intensive care unit (ICU) to optimize nutrition therapy and reduce mortality. While incapable of blunting the catabolic response, protein doses in this range may be needed to best stimulate new protein synthesis and preserve muscle mass. Quality of protein (determined by source, content and ratio of amino acids, and digestibility) affects nutrient sensing pathways such as the mammalian target of rapamycin. Achieving protein goals the first week following admission to the ICU should take precedence over meeting energy goals. High-protein hypocaloric (providing 80%-90% of caloric requirements) feeding may evolve as the best strategy during the initial phase of critical illness to avoid overfeeding, improve insulin sensitivity, and maintain body protein homeostasis, especially in the patient at high nutrition risk. This article provides a set of recommendations based on assessment of the current literature to guide healthcare professionals in clinical practice at this time, as well as a list of potential topics to guide investigators for purposes of research in the future.

KW - amino acids

KW - enteral nutrition

KW - lean body mass

KW - parenteral nutrition

KW - protein

UR - http://www.scopus.com/inward/record.url?scp=85018734119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018734119&partnerID=8YFLogxK

U2 - 10.1177/0884533617693610

DO - 10.1177/0884533617693610

M3 - Article

C2 - 28388374

AN - SCOPUS:85018734119

VL - 32

SP - 142S-151S

JO - Nutrition in Clinical Practice

JF - Nutrition in Clinical Practice

SN - 0884-5336

IS - 1_suppl

ER -