TY - JOUR
T1 - 18FDG-PeT/CT is useful in the follow-up of surgically treated patients with oesophageal adenocarcinoma
AU - Cuellar, Sonia L.Betancourt
AU - Palacio, Diana P.
AU - Wu, Carol C.
AU - Carter, Brett W.
AU - Correa, Arlene M.
AU - Hofstetter, Wayne L.
AU - Marom, Edith M.
N1 - Publisher Copyright:
© 2018 The Authors.
PY - 2018
Y1 - 2018
N2 - Objective: The purpose of this study was to evaluate fludeoxyglucose-positron emission tomography/CT's (FDG-PET/CT) performance in the follow up of patients with surgically treated oesophageal adenocarcinoma. Methods: The follow-up FDG-PET/CT scans of 162 consecutive patients with surgically treated oesophageal adenocarcinoma were retrospectively reviewed. Histopathological and/or imaging examinations confrmed recurrent disease. The accuracy, sensitivity, specifcity and negative and positive predictive values were calculated. Results: Recurrence occurred in 71 (43%) patients, usually within the frst year following surgery (60%) and in more than one site (76%). The sensitivity, specifcity, positive-predictive value, negative-predictive value and accuracy of FDG-PET/CT for anastomotic recurrence were 77, 76, 16, 98 and 76%; for regional nodal recurrence were 88, 85, 43, 97 and 86%; and for distant metastatic recurrence were: 97, 96, 91, 99 and 96%. In 5 of the 42 patients (12%) with distant metastases, the metastatic sites were outside the area covered by a conventional follow-up chest-abdomen CT and in 4 patients (9%) metastases were barely perceptible on the CT component of the FDG-PET/CT and consequently were unlikely to be detected without the aid of the FDG uptake. Conclusion: FDG PET/CT is accurate in detecting oesophageal adenocarcinoma recurrence, especially within the frst post-operative year when most recurrences occur, and is useful in identifying patients with a solitary metastasis. Advances in knowledge: FDG-PET/CT should be considered as a valuable tool in the routine follow up of surgically treated oesophageal cancer patients within the frst 2 years after surgery.
AB - Objective: The purpose of this study was to evaluate fludeoxyglucose-positron emission tomography/CT's (FDG-PET/CT) performance in the follow up of patients with surgically treated oesophageal adenocarcinoma. Methods: The follow-up FDG-PET/CT scans of 162 consecutive patients with surgically treated oesophageal adenocarcinoma were retrospectively reviewed. Histopathological and/or imaging examinations confrmed recurrent disease. The accuracy, sensitivity, specifcity and negative and positive predictive values were calculated. Results: Recurrence occurred in 71 (43%) patients, usually within the frst year following surgery (60%) and in more than one site (76%). The sensitivity, specifcity, positive-predictive value, negative-predictive value and accuracy of FDG-PET/CT for anastomotic recurrence were 77, 76, 16, 98 and 76%; for regional nodal recurrence were 88, 85, 43, 97 and 86%; and for distant metastatic recurrence were: 97, 96, 91, 99 and 96%. In 5 of the 42 patients (12%) with distant metastases, the metastatic sites were outside the area covered by a conventional follow-up chest-abdomen CT and in 4 patients (9%) metastases were barely perceptible on the CT component of the FDG-PET/CT and consequently were unlikely to be detected without the aid of the FDG uptake. Conclusion: FDG PET/CT is accurate in detecting oesophageal adenocarcinoma recurrence, especially within the frst post-operative year when most recurrences occur, and is useful in identifying patients with a solitary metastasis. Advances in knowledge: FDG-PET/CT should be considered as a valuable tool in the routine follow up of surgically treated oesophageal cancer patients within the frst 2 years after surgery.
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U2 - 10.1259/bjr.20170341
DO - 10.1259/bjr.20170341
M3 - Article
C2 - 29125331
AN - SCOPUS:85041320608
SN - 0007-1285
VL - 91
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1082
M1 - 20170341
ER -