suPAR, a Circulating Kidney Disease Factor

Changli Wei; Ryan Spear; Eunsil Hahm; Jochen Reiser

doi:10.3389/fmed.2021.745838

suPAR, a Circulating Kidney Disease Factor

Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.

Original language	English (US)
Article number	745838
Journal	Frontiers in Medicine
Volume	8
DOIs	https://doi.org/10.3389/fmed.2021.745838
State	Published - Oct 6 2021
Externally published	Yes

Keywords

isoform
kidney
proteinuric disease
suPAR
uPAR

ASJC Scopus subject areas

General Medicine

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10.3389/fmed.2021.745838

Cite this

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title = "suPAR, a Circulating Kidney Disease Factor",

abstract = "Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.",

keywords = "isoform, kidney, proteinuric disease, suPAR, uPAR",

author = "Changli Wei and Ryan Spear and Eunsil Hahm and Jochen Reiser",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Wei, Spear, Hahm and Reiser.",

year = "2021",

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language = "English (US)",

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T1 - suPAR, a Circulating Kidney Disease Factor

AU - Wei, Changli

AU - Spear, Ryan

AU - Hahm, Eunsil

AU - Reiser, Jochen

PY - 2021/10/6

Y1 - 2021/10/6

N2 - Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.

AB - Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.

KW - isoform

KW - kidney

KW - proteinuric disease

KW - suPAR

KW - uPAR

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U2 - 10.3389/fmed.2021.745838

DO - 10.3389/fmed.2021.745838

M3 - Review article

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VL - 8

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 745838

ER -

suPAR, a Circulating Kidney Disease Factor

Abstract

Keywords

ASJC Scopus subject areas

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