TY - JOUR
T1 - Superoxide dismutase and catalase
T2 - A possible role in established pancreatitis
AU - Guice, Karen S.
AU - Miller, Donald E.
AU - Oldham, Keith T.
AU - Townsend, Courtney M.
AU - Thompson, James C.
PY - 1986/1
Y1 - 1986/1
N2 - The mechanism of cerulein-induced acute pancreatitis may involve the production of free radicals in excess of the capacity of endogenous intracellular scavengers. These radicals destroy the cellular membranes, releasing digestive enzymes and cellular proteins into the interstitium. Thereafter, a cascade of events, including polymorphonuclear infiltration and complement activation, leads to pancreatic destruction. The present study demonstrates that superoxide dismutase and catalase reduce the ultrastructural and biochemical injury associated with ceruleininduced acute pancreatitis in rats. Pretreatment with superoxide dismutase and catalase 30 minutes before injury did not appear to be protective, presumably because the half-life of intravenous superoxide dismutase is only 6 minutes [34]. This and similar studies suggest a potential clinical role for free radical scavengers in acute established pancreatitis.
AB - The mechanism of cerulein-induced acute pancreatitis may involve the production of free radicals in excess of the capacity of endogenous intracellular scavengers. These radicals destroy the cellular membranes, releasing digestive enzymes and cellular proteins into the interstitium. Thereafter, a cascade of events, including polymorphonuclear infiltration and complement activation, leads to pancreatic destruction. The present study demonstrates that superoxide dismutase and catalase reduce the ultrastructural and biochemical injury associated with ceruleininduced acute pancreatitis in rats. Pretreatment with superoxide dismutase and catalase 30 minutes before injury did not appear to be protective, presumably because the half-life of intravenous superoxide dismutase is only 6 minutes [34]. This and similar studies suggest a potential clinical role for free radical scavengers in acute established pancreatitis.
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U2 - 10.1016/0002-9610(86)90027-9
DO - 10.1016/0002-9610(86)90027-9
M3 - Article
C2 - 2418699
AN - SCOPUS:0022608170
SN - 0002-9610
VL - 151
SP - 163
EP - 169
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 1
ER -