Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

Premkumar Christadoss, Norman Talal, Jon Lindstrom, Gabriel Fernandes

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Calorie restriction is known to preserve the immunologic function and prolong the life span of autoimmune-susceptible mice. In order to determine the influence of calorie restriction on cellular and humoral immunity, we tested lymphocyte proliferative response and antibody response to T-dependent antigens in C57Bl/6 mice maintained on restricted diets. C57Bl/6 mice fed a low-calorie diet demonstrated a marked reduction in T-dependent-antigen-specific lymphocyte proliferation and antibody response when compared to mice fed ad libitum. The depressed lymphocyte response seen in calorie-restricted animals is attributed to a defect in both the macrophages and T cells in antigen processing, presentation, and/or proliferation.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCellular Immunology
Volume88
Issue number1
DOIs
StatePublished - Oct 1 1984
Externally publishedYes

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Viral Tumor Antigens
Humoral Immunity
Cellular Immunity
Antigen Presentation
Lymphocytes
Antibody Formation
Caloric Restriction
Macrophages
Diet
T-Lymphocytes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction. / Christadoss, Premkumar; Talal, Norman; Lindstrom, Jon; Fernandes, Gabriel.

In: Cellular Immunology, Vol. 88, No. 1, 01.10.1984, p. 1-8.

Research output: Contribution to journalArticle

Christadoss, Premkumar ; Talal, Norman ; Lindstrom, Jon ; Fernandes, Gabriel. / Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction. In: Cellular Immunology. 1984 ; Vol. 88, No. 1. pp. 1-8.
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