Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

Premkumar Christadoss; Norman Talal; Jon Lindstrom; Gabriel Fernandes

doi:10.1016/0008-8749(84)90046-7

Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

Premkumar Christadoss, Norman Talal, Jon Lindstrom, Gabriel Fernandes

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Calorie restriction is known to preserve the immunologic function and prolong the life span of autoimmune-susceptible mice. In order to determine the influence of calorie restriction on cellular and humoral immunity, we tested lymphocyte proliferative response and antibody response to T-dependent antigens in C57Bl/6 mice maintained on restricted diets. C57Bl/6 mice fed a low-calorie diet demonstrated a marked reduction in T-dependent-antigen-specific lymphocyte proliferation and antibody response when compared to mice fed ad libitum. The depressed lymphocyte response seen in calorie-restricted animals is attributed to a defect in both the macrophages and T cells in antigen processing, presentation, and/or proliferation.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Cellular Immunology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(84)90046-7
State	Published - Oct 1 1984
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(84)90046-7

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title = "Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction",

abstract = "Calorie restriction is known to preserve the immunologic function and prolong the life span of autoimmune-susceptible mice. In order to determine the influence of calorie restriction on cellular and humoral immunity, we tested lymphocyte proliferative response and antibody response to T-dependent antigens in C57Bl/6 mice maintained on restricted diets. C57Bl/6 mice fed a low-calorie diet demonstrated a marked reduction in T-dependent-antigen-specific lymphocyte proliferation and antibody response when compared to mice fed ad libitum. The depressed lymphocyte response seen in calorie-restricted animals is attributed to a defect in both the macrophages and T cells in antigen processing, presentation, and/or proliferation.",

author = "Premkumar Christadoss and Norman Talal and Jon Lindstrom and Gabriel Fernandes",

note = "Funding Information: {\textquoteright} This work was supported by grants from the Muscular Dystrophy Association, AC 034 17, NS 11323, and the General Medical Research Service of the Veterans Administration. * To whom correspondence should be addressed at: Department of Medicine, Division of Clinical Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Tex. 78284.",

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T1 - Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

AU - Christadoss, Premkumar

AU - Talal, Norman

AU - Lindstrom, Jon

AU - Fernandes, Gabriel

N1 - Funding Information: ’ This work was supported by grants from the Muscular Dystrophy Association, AC 034 17, NS 11323, and the General Medical Research Service of the Veterans Administration. * To whom correspondence should be addressed at: Department of Medicine, Division of Clinical Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Tex. 78284.

PY - 1984/10/1

Y1 - 1984/10/1

N2 - Calorie restriction is known to preserve the immunologic function and prolong the life span of autoimmune-susceptible mice. In order to determine the influence of calorie restriction on cellular and humoral immunity, we tested lymphocyte proliferative response and antibody response to T-dependent antigens in C57Bl/6 mice maintained on restricted diets. C57Bl/6 mice fed a low-calorie diet demonstrated a marked reduction in T-dependent-antigen-specific lymphocyte proliferation and antibody response when compared to mice fed ad libitum. The depressed lymphocyte response seen in calorie-restricted animals is attributed to a defect in both the macrophages and T cells in antigen processing, presentation, and/or proliferation.

AB - Calorie restriction is known to preserve the immunologic function and prolong the life span of autoimmune-susceptible mice. In order to determine the influence of calorie restriction on cellular and humoral immunity, we tested lymphocyte proliferative response and antibody response to T-dependent antigens in C57Bl/6 mice maintained on restricted diets. C57Bl/6 mice fed a low-calorie diet demonstrated a marked reduction in T-dependent-antigen-specific lymphocyte proliferation and antibody response when compared to mice fed ad libitum. The depressed lymphocyte response seen in calorie-restricted animals is attributed to a defect in both the macrophages and T cells in antigen processing, presentation, and/or proliferation.

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Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

Abstract

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