Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins

Osamu Noyori, Eri Nakayama, Junki Maruyama, Reiko Yoshida, Ayato Takada

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expressed on cell surfaces formed a steric shield over the Fas molecule and that GP-expressing cells showed resistance to cell death induced by a Fas agonistic antibody. These results suggest that filovirus GP-mediated steric shielding may interfere with the Fas-induced apoptotic signal transduction in infected cells and serve as an immune evasion mechanism for filoviruses.

Original languageEnglish (US)
Pages (from-to)994-998
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume441
Issue number4
DOIs
StatePublished - Nov 29 2013
Externally publishedYes

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Keywords

  • Apoptosis
  • Fas
  • Filovirus
  • Glycoprotein
  • Steric shielding

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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