Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment

S. Vaidya, R. Mamlok, C. W. Daeschner, J. Williams, J. Ruth, R. M. Goldblum

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Simultaneous engraftment of maternal T cells and T cells from unrelated transfusion donor in an infant with severe combined immunodeficiency disease (SCID) was identified by HLA typing blood lymphocytes of the patient, her triplet siblings, parents, and the platelet donor from whom the patient received nonirradiated platelet transfusion. T cell grafts from both the mother and platelet donor were stable for several months, but the graft-versus-host reactions (GvHR) remained mild and immune function was deficient. We hypothesize that immunosuppressive effects of a maternal-fetal GvHR may have modified the expected lethal GvHR from platelet donor's T cells.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume13
Issue number2
StatePublished - 1991

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Severe Combined Immunodeficiency
Mothers
T-Lymphocytes
Transplants
Blood Platelets
Tissue Donors
Histocompatibility Testing
Unrelated Donors
Platelet Transfusion
Immunosuppressive Agents
Siblings
Parents
Lymphocytes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Vaidya, S., Mamlok, R., Daeschner, C. W., Williams, J., Ruth, J., & Goldblum, R. M. (1991). Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment. American Journal of Pediatric Hematology/Oncology, 13(2), 172-175.

Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment. / Vaidya, S.; Mamlok, R.; Daeschner, C. W.; Williams, J.; Ruth, J.; Goldblum, R. M.

In: American Journal of Pediatric Hematology/Oncology, Vol. 13, No. 2, 1991, p. 172-175.

Research output: Contribution to journalArticle

Vaidya, S, Mamlok, R, Daeschner, CW, Williams, J, Ruth, J & Goldblum, RM 1991, 'Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment', American Journal of Pediatric Hematology/Oncology, vol. 13, no. 2, pp. 172-175.
Vaidya, S. ; Mamlok, R. ; Daeschner, C. W. ; Williams, J. ; Ruth, J. ; Goldblum, R. M. / Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment. In: American Journal of Pediatric Hematology/Oncology. 1991 ; Vol. 13, No. 2. pp. 172-175.
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