Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal t cell engraftment

Smita Vaidya, Robert Mamlok, Charles W. Daeschner, June Williams, Randall M. Goldblum, Jim Ruth

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Simultaneous engraftment of maternal T cells and T cells from unrelated transfusion donor in an infant with severe combined immunodeficiency disease (SCID) was identified by HLA typing blood lymphocytes of the patient, her triplet siblings, parents, and the platelet donor from whom the patient received nonirradiated platelet transfusion. T cell grafts from both the mother and platelet donor were stable for several months, but the graft-versus-host reactions (GvHR) remained mild and immune function was deficient. We hypothesize that immunosuppressive effects of a maternal-fetal GvHR may have modified the expected lethal GvHR from platelet donor’s T cells.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume13
Issue number2
DOIs
StatePublished - 1991

Keywords

  • Graft-versus-host reactions (GvHR)
  • Human leucocyte antigen (HLA)
  • Severe combined immunodeficiency disease (SCID)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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