Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell

James Goodwin, A. D. Bankhurst, R. P. Messner

Research output: Contribution to journalArticle

615 Citations (Scopus)

Abstract

Small amounts of PGE inhibited mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is ~10-7 M, and this is reduced by ~10-8 M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultures much better than PWM cultures, suggesting a differential effect of PGE on T-cell vs. B-cell function. In vitro blockade of PG synthesis results in ~50% increase in [3H]thymidine incorporation in PHA cultures. PGE is produced endogenously in PHA cultures by glass adherent suppressor cells.

Original languageEnglish (US)
Pages (from-to)1719-1734
Number of pages16
JournalJournal of Experimental Medicine
Volume146
Issue number6
StatePublished - 1977
Externally publishedYes

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Prostaglandins E
Prostaglandins
T-Lymphocytes
Thymidine
Mitogens
Inhibitory Concentration 50
Glass
B-Lymphocytes
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. / Goodwin, James; Bankhurst, A. D.; Messner, R. P.

In: Journal of Experimental Medicine, Vol. 146, No. 6, 1977, p. 1719-1734.

Research output: Contribution to journalArticle

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