Suppression of human T-cell mitogenesis by prostaglandin: Existence of a prostaglandin-producing suppressor cell*

James S. Goodwin, Arthur D. Bankhurst, Ronald P. Messner

Research output: Contribution to journalArticle

617 Scopus citations

Abstract

Small amounts of PGE inhibit mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is -10-7 M, and this is reduced to -10-8 M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultures much better than PWM cultures, suggesting a differential effect of PGE on T-cell vs. B-cell function. In vitro blockade of PG synthesis results in -50% increase in [3H]thymidine incorporation in PHA cultures. PGE is produced endogenously in PHA cultures by glass adherent suppressor cells.

Original languageEnglish (US)
Pages (from-to)1719-1734
Number of pages16
JournalJournal of Experimental Medicine
Volume146
Issue number6
DOIs
StatePublished - Dec 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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