Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid

Guillermo A. Tate, Brian F. Mandell, Rashida A. Karmali, Michael Laposata, Daniel G. Baker, H. Ralph Schumacher, Robert B. Zurier

Research output: Contribution to journalArticle

73 Scopus citations


A subcutaneous air pouch formed in Sprague‐Dawley rats was used to study the effect of diets enriched in γ‐linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals. The GLA‐enriched diet suppressed significantly the cellular phase of inflammation (polymorphonuclear leukocyte accumulation, crystal phagocytosis, and lysosomal enzyme activity), but it had little effect on the fluid phase (exudate volume and protein concentration). In contrast, the EPA‐enriched diet suppressed the fluid phase but not the cellular phase of inflammation. The findings indicate that the fluid and cellular phases of acute inflammation can be controlled independently. A combined diet of fish oil and plant seed oil (EPA‐enriched and GLA‐enriched) reduced both the cellular and fluid phases of inflammation. Thus, dietary provision of alternative substrates for oxidative metabolism (other than arachidonic acid) modifies monosodium urate crystal‐induced acute inflammation.

Original languageEnglish (US)
Pages (from-to)1543-1551
Number of pages9
JournalArthritis & Rheumatism
Issue number12
StatePublished - Dec 1988
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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