Suppression of mouse skin allograft rejection by protein A-Yersiniae V antigen fusion peptide

Vladimir Motin, Susan M. Kutas, Robert R. Brubaker

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

V antigen is an established virulence factor of Yersinia pestis, the causative agent of bubonic plague. Injection of homogenous staphylococcal protein A-V antigen fusion peptide into mice was previously found to suppress tumor necrosis factor-α and interferon-γ necessary for generation of protective granulomas. Here, we show that BALB/c mice receiving daily intraperitoneal injections of 100 μg of control protein A initiated rejection of C57BL/6 mouse tail skin grafts after 6.2±1.1 days. This time doubled to 12.2±1.4 days upon similar administration of protein A-V antigen fusion peptide (P<0.001); times of total allograft retention remained constant. This finding indicates that V antigen can postpone inflammation known to be associated with recognition and destruction of foreign tissue by T lymphocytes.

Original languageEnglish (US)
Pages (from-to)1040-1042
Number of pages3
JournalTransplantation
Volume63
Issue number7
DOIs
StatePublished - Apr 15 1997
Externally publishedYes

Fingerprint

Staphylococcal Protein A
Allografts
Antigens
Skin
Peptides
Yersinia pestis
Plague
Virulence Factors
Granuloma
Intraperitoneal Injections
Inbred C57BL Mouse
Interferons
Tail
Tumor Necrosis Factor-alpha
Inflammation
T-Lymphocytes
Transplants
Injections
Yersinia LcrV protein

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Suppression of mouse skin allograft rejection by protein A-Yersiniae V antigen fusion peptide. / Motin, Vladimir; Kutas, Susan M.; Brubaker, Robert R.

In: Transplantation, Vol. 63, No. 7, 15.04.1997, p. 1040-1042.

Research output: Contribution to journalArticle

Motin, Vladimir ; Kutas, Susan M. ; Brubaker, Robert R. / Suppression of mouse skin allograft rejection by protein A-Yersiniae V antigen fusion peptide. In: Transplantation. 1997 ; Vol. 63, No. 7. pp. 1040-1042.
@article{e5c5b699d1054aa69c3f168db817be71,
title = "Suppression of mouse skin allograft rejection by protein A-Yersiniae V antigen fusion peptide",
abstract = "V antigen is an established virulence factor of Yersinia pestis, the causative agent of bubonic plague. Injection of homogenous staphylococcal protein A-V antigen fusion peptide into mice was previously found to suppress tumor necrosis factor-α and interferon-γ necessary for generation of protective granulomas. Here, we show that BALB/c mice receiving daily intraperitoneal injections of 100 μg of control protein A initiated rejection of C57BL/6 mouse tail skin grafts after 6.2±1.1 days. This time doubled to 12.2±1.4 days upon similar administration of protein A-V antigen fusion peptide (P<0.001); times of total allograft retention remained constant. This finding indicates that V antigen can postpone inflammation known to be associated with recognition and destruction of foreign tissue by T lymphocytes.",
author = "Vladimir Motin and Kutas, {Susan M.} and Brubaker, {Robert R.}",
year = "1997",
month = "4",
day = "15",
doi = "10.1097/00007890-199704150-00027",
language = "English (US)",
volume = "63",
pages = "1040--1042",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Suppression of mouse skin allograft rejection by protein A-Yersiniae V antigen fusion peptide

AU - Motin, Vladimir

AU - Kutas, Susan M.

AU - Brubaker, Robert R.

PY - 1997/4/15

Y1 - 1997/4/15

N2 - V antigen is an established virulence factor of Yersinia pestis, the causative agent of bubonic plague. Injection of homogenous staphylococcal protein A-V antigen fusion peptide into mice was previously found to suppress tumor necrosis factor-α and interferon-γ necessary for generation of protective granulomas. Here, we show that BALB/c mice receiving daily intraperitoneal injections of 100 μg of control protein A initiated rejection of C57BL/6 mouse tail skin grafts after 6.2±1.1 days. This time doubled to 12.2±1.4 days upon similar administration of protein A-V antigen fusion peptide (P<0.001); times of total allograft retention remained constant. This finding indicates that V antigen can postpone inflammation known to be associated with recognition and destruction of foreign tissue by T lymphocytes.

AB - V antigen is an established virulence factor of Yersinia pestis, the causative agent of bubonic plague. Injection of homogenous staphylococcal protein A-V antigen fusion peptide into mice was previously found to suppress tumor necrosis factor-α and interferon-γ necessary for generation of protective granulomas. Here, we show that BALB/c mice receiving daily intraperitoneal injections of 100 μg of control protein A initiated rejection of C57BL/6 mouse tail skin grafts after 6.2±1.1 days. This time doubled to 12.2±1.4 days upon similar administration of protein A-V antigen fusion peptide (P<0.001); times of total allograft retention remained constant. This finding indicates that V antigen can postpone inflammation known to be associated with recognition and destruction of foreign tissue by T lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=0030894902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030894902&partnerID=8YFLogxK

U2 - 10.1097/00007890-199704150-00027

DO - 10.1097/00007890-199704150-00027

M3 - Article

VL - 63

SP - 1040

EP - 1042

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 7

ER -