Suppressor cells of mitogen-induced lymphocyte proliferation in the peripheral blood of patients with common variable hypogammaglobulinemia

Yukinobu Ichikawa, Emilio Gonzalez, Jerry C. Daniels

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Diminished lymphocyte proliferative responses to several mitogens have been demonstrated in peripheral blood lymphocytes (PBL) from patients with common variable hypogammaglobulinemia. The mechanism is obscure, although intrinsic cellular defects have been suggested in both T and B cells. We studied PBL from three patients with this disease, who showed diminished lymphocyte proliferative responses to pokeweed mitogen and/or concanavalin A. Decreased OKT4-reactive helper T-cell subsets as well as increased OKT8-reactive suppressor T-cell subsets, as defined by recently developed monoclonal antibodies, were identified in PBL from these patients. In addition, activated suppressor T-cell function modulating the proliferative responses of autologous and/or allogeneic lymphocytes was demonstrated in these patients by coculture of the patients' PBL with allogeneic PBL and by elimination of T-cell subsets from the patients' PBL.

Original languageEnglish (US)
Pages (from-to)252-263
Number of pages12
JournalClinical Immunology and Immunopathology
Volume25
Issue number2
DOIs
StatePublished - 1982

Fingerprint

Common Variable Immunodeficiency
Mitogens
Lymphocytes
T-Lymphocyte Subsets
T-Lymphocytes
Pokeweed Mitogens
Concanavalin A
Helper-Inducer T-Lymphocytes
Coculture Techniques
B-Lymphocytes
Monoclonal Antibodies

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Suppressor cells of mitogen-induced lymphocyte proliferation in the peripheral blood of patients with common variable hypogammaglobulinemia. / Ichikawa, Yukinobu; Gonzalez, Emilio; Daniels, Jerry C.

In: Clinical Immunology and Immunopathology, Vol. 25, No. 2, 1982, p. 252-263.

Research output: Contribution to journalArticle

@article{79ea3fd2daa7447d8bc767654e1ee613,
title = "Suppressor cells of mitogen-induced lymphocyte proliferation in the peripheral blood of patients with common variable hypogammaglobulinemia",
abstract = "Diminished lymphocyte proliferative responses to several mitogens have been demonstrated in peripheral blood lymphocytes (PBL) from patients with common variable hypogammaglobulinemia. The mechanism is obscure, although intrinsic cellular defects have been suggested in both T and B cells. We studied PBL from three patients with this disease, who showed diminished lymphocyte proliferative responses to pokeweed mitogen and/or concanavalin A. Decreased OKT4-reactive helper T-cell subsets as well as increased OKT8-reactive suppressor T-cell subsets, as defined by recently developed monoclonal antibodies, were identified in PBL from these patients. In addition, activated suppressor T-cell function modulating the proliferative responses of autologous and/or allogeneic lymphocytes was demonstrated in these patients by coculture of the patients' PBL with allogeneic PBL and by elimination of T-cell subsets from the patients' PBL.",
author = "Yukinobu Ichikawa and Emilio Gonzalez and Daniels, {Jerry C.}",
year = "1982",
doi = "10.1016/0090-1229(82)90188-X",
language = "English (US)",
volume = "25",
pages = "252--263",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Suppressor cells of mitogen-induced lymphocyte proliferation in the peripheral blood of patients with common variable hypogammaglobulinemia

AU - Ichikawa, Yukinobu

AU - Gonzalez, Emilio

AU - Daniels, Jerry C.

PY - 1982

Y1 - 1982

N2 - Diminished lymphocyte proliferative responses to several mitogens have been demonstrated in peripheral blood lymphocytes (PBL) from patients with common variable hypogammaglobulinemia. The mechanism is obscure, although intrinsic cellular defects have been suggested in both T and B cells. We studied PBL from three patients with this disease, who showed diminished lymphocyte proliferative responses to pokeweed mitogen and/or concanavalin A. Decreased OKT4-reactive helper T-cell subsets as well as increased OKT8-reactive suppressor T-cell subsets, as defined by recently developed monoclonal antibodies, were identified in PBL from these patients. In addition, activated suppressor T-cell function modulating the proliferative responses of autologous and/or allogeneic lymphocytes was demonstrated in these patients by coculture of the patients' PBL with allogeneic PBL and by elimination of T-cell subsets from the patients' PBL.

AB - Diminished lymphocyte proliferative responses to several mitogens have been demonstrated in peripheral blood lymphocytes (PBL) from patients with common variable hypogammaglobulinemia. The mechanism is obscure, although intrinsic cellular defects have been suggested in both T and B cells. We studied PBL from three patients with this disease, who showed diminished lymphocyte proliferative responses to pokeweed mitogen and/or concanavalin A. Decreased OKT4-reactive helper T-cell subsets as well as increased OKT8-reactive suppressor T-cell subsets, as defined by recently developed monoclonal antibodies, were identified in PBL from these patients. In addition, activated suppressor T-cell function modulating the proliferative responses of autologous and/or allogeneic lymphocytes was demonstrated in these patients by coculture of the patients' PBL with allogeneic PBL and by elimination of T-cell subsets from the patients' PBL.

UR - http://www.scopus.com/inward/record.url?scp=0019991676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019991676&partnerID=8YFLogxK

U2 - 10.1016/0090-1229(82)90188-X

DO - 10.1016/0090-1229(82)90188-X

M3 - Article

VL - 25

SP - 252

EP - 263

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 2

ER -