Suppressor leukocytes in anergic patients with solid tumors

A. D. Bankhurst, G. R. Kauffman, J. S. Goodwin, J. H. Saiki, J. H. Saiers, R. C. Williams

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Anergic patients with solid tumors were studied for the presence of suppressor cells which could be responsible for their significantly impaired phytohemagglutinin induced lymphocyte proliferation. Three types of suppressor cell assays were measured. First, no increased activity of prostaglandin producing suppressor cells was found in 10 cancer patients. Second, 5 cancer patients did not have significantly increased activity of short-lived suppressor cells in comparison with normal subjects. third, no enhanced activity of concanavalin A induced suppressor cells was seen in 6 patients. This study emphasizes that the in vitro T cell immunodeficiency in this group of cancer patients was not due to suppressor cells as measured by conventional in vitro assays and emphasizes the potential importance of a loss of responder cells or other suppressor mechanisms in immune deficient patients with solid tumors.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalJournal of Clinical and Laboratory Immunology
Volume3
Issue number3
StatePublished - Sep 12 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Bankhurst, A. D., Kauffman, G. R., Goodwin, J. S., Saiki, J. H., Saiers, J. H., & Williams, R. C. (1980). Suppressor leukocytes in anergic patients with solid tumors. Journal of Clinical and Laboratory Immunology, 3(3), 159-163.