Surface-enhanced Raman spectroscopy for the in vitro and ex vivo detection of excitatory amino acids

D. Patrick O'Neal, Massoud Motamedi, Jefferson Chen, Gerard L. Cote

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Traditional methods for the detection of excitatory amino acids, which have been linked to secondary injury following head trauma, can be excessively time consuming clinically. A near real-time measurement system could provide clinical information in anticipation of pharmaceutical intervention for head injured patients. Our studies have shown that Surface-Enhanced Raman Spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vitro excitatory amino acids using short scan times. Employing a damage model for ischemia, preliminary ex vivo rat extracellular brain fluid analysis shows an intriguing correlation between SERS spectral features and expected Glutamate concentration fluctuations following head injuries.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Biomedical Applications of Raman Spectroscopy - San Jose, Ca, USA
Duration: Jan 25 1999Jan 26 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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