Surface-enhanced Raman spectroscopy for the in vitro and ex vivo detection of excitatory amino acids

D. Patrick O'Neal, Massoud Motamedi, Jefferson Chen, Gerard L. Cote

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Traditional methods for the detection of excitatory amino acids, which have been linked to secondary injury following head trauma, can be excessively time consuming clinically. A near real-time measurement system could provide clinical information in anticipation of pharmaceutical intervention for head injured patients. Our studies have shown that Surface-Enhanced Raman Spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vitro excitatory amino acids using short scan times. Employing a damage model for ischemia, preliminary ex vivo rat extracellular brain fluid analysis shows an intriguing correlation between SERS spectral features and expected Glutamate concentration fluctuations following head injuries.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages211-216
Number of pages6
Volume3608
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Biomedical Applications of Raman Spectroscopy - San Jose, Ca, USA
Duration: Jan 25 1999Jan 26 1999

Other

OtherProceedings of the 1999 Biomedical Applications of Raman Spectroscopy
CitySan Jose, Ca, USA
Period1/25/991/26/99

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

O'Neal, D. P., Motamedi, M., Chen, J., & Cote, G. L. (1999). Surface-enhanced Raman spectroscopy for the in vitro and ex vivo detection of excitatory amino acids. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3608, pp. 211-216). Society of Photo-Optical Instrumentation Engineers.