Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats

D. Patrick O'Neal, Massoud Motamedi, Jefferson Chen, Gerard L. Cote

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The detection of severe brain trauma remains difficult when employing traditional methods in part due to the pathophysiological complexity of the condition. Current brain trauma detection includes schemes that require bulky, expensive equipment to deduce regional cerebral blood flow. These methods are difficult to use in conjunction with patients requiring ongoing intensive care and constant monitoring. Our previous studies have shown that Surface-enhanced Raman spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vitro brain analytes linked to brain trauma using short scan times. More recently, after implementing a damage model for ischemia in rats, an ex vivo analysis of brain microdialysis samples shows a correlation between SERS spectral features and the occurrence and location of known localized ischema. A near real-time measurement system could provide relevant clinical information in anticipation of surgical or pharmaceutical interventions for severely head injured patients.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages191-196
Number of pages6
Volume3918
StatePublished - 2000
Externally publishedYes
EventBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000

Other

OtherBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques
CitySan Jose, CA, USA
Period1/26/001/27/00

Fingerprint

rats
brain
Raman spectroscopy
Rats
Brain
ischemia
blood flow
Time measurement
Colloids
Drug products
colloids
Silver
Blood
silver
time measurement
occurrences
damage
Monitoring

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

O'Neal, D. P., Motamedi, M., Chen, J., & Cote, G. L. (2000). Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3918, pp. 191-196). Society of Photo-Optical Instrumentation Engineers.

Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats. / O'Neal, D. Patrick; Motamedi, Massoud; Chen, Jefferson; Cote, Gerard L.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3918 Society of Photo-Optical Instrumentation Engineers, 2000. p. 191-196.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

O'Neal, DP, Motamedi, M, Chen, J & Cote, GL 2000, Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3918, Society of Photo-Optical Instrumentation Engineers, pp. 191-196, Biomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques, San Jose, CA, USA, 1/26/00.
O'Neal DP, Motamedi M, Chen J, Cote GL. Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3918. Society of Photo-Optical Instrumentation Engineers. 2000. p. 191-196
O'Neal, D. Patrick ; Motamedi, Massoud ; Chen, Jefferson ; Cote, Gerard L. / Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3918 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 191-196
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