Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats

D. Patrick O'Neal, Massoud Motamedi, Jefferson Chen, Gerard L. Cote

Research output: Contribution to journalConference articlepeer-review

6 Scopus citations


The detection of severe brain trauma remains difficult when employing traditional methods in part due to the pathophysiological complexity of the condition. Current brain trauma detection includes schemes that require bulky, expensive equipment to deduce regional cerebral blood flow. These methods are difficult to use in conjunction with patients requiring ongoing intensive care and constant monitoring. Our previous studies have shown that Surface-enhanced Raman spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vitro brain analytes linked to brain trauma using short scan times. More recently, after implementing a damage model for ischemia in rats, an ex vivo analysis of brain microdialysis samples shows a correlation between SERS spectral features and the occurrence and location of known localized ischema. A near real-time measurement system could provide relevant clinical information in anticipation of surgical or pharmaceutical interventions for severely head injured patients.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2000
Externally publishedYes
EventBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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