Surgeon-performed touch preparation of breast core needle biopsies may provide accurate same-day diagnosis and expedite treatment planning

Pranjali V. Gadgil, Soheila Korourian, Sharp Malak, Daniela Ochoa, Riley Lipschitz, Ronda Henry-Tillman, Vicki Klimberg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. We aimed to determine the accuracy of surgeon-performed touch-preparation cytology (TPC) of breast core-needle biopsies (CNB) and the ability to use TPC results to initiate treatment planning at the same patient visit. Methods. A single-institution retrospective review of TPC results of ultrasound-guided breast CNB was performed. All TPC slides were prepared by surgeons performing the biopsy and interpreted by the pathologist. TPC results were reported as positive/suspicious, atypical, negative/benign, or deferred; these were compared with final pathology of cores to calculate accuracy. Treatment planning was noted as having taken place if the patient had requisition of advanced imaging, referrals, or surgical planning undertaken during the same visit. Results. Four hundred forty-seven CNB specimens with corresponding TPC were evaluated from 434 patient visits, and 203 samples (45.4 %) were malignant on final pathology. When the deferred, atypical, and benign results were considered negative and positive/suspicious results were considered positive, sensitivity and specificity were 83.7 % (77.9-88.5 %) and 98.4 % (95.9-99.6 %), respectively; positive and negative predictive values were 97.7 % (94.2-99.4 %) and 87.9 % (83.4-91.5 %), respectively. In practice, patients with atypical or deferred results were asked to await final pathology. An accurate same-day diagnosis (TPC positive/suspicious) was hence feasible in 83.7 % (170 of 203) of malignant and 79.5 % (194 of 244) of benign cases (TPC negative). Of patients who had a same-day diagnosis of a new malignancy, 77.3 % had treatment planning initiated at the same visit. Conclusions. Surgeon-performed TPC of breast CNB is an accurate method of same-day diagnosis that allows treatment planning to be initiated at the same visit and may serve to expedite patient care.

Original languageEnglish (US)
Pages (from-to)1215-1221
Number of pages7
JournalAnnals of Surgical Oncology
Volume21
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Large-Core Needle Biopsy
Touch
Cell Biology
Breast
Therapeutics
Pathology
Surgeons
Aptitude
Patient Care
Referral and Consultation
Biopsy
Sensitivity and Specificity

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Surgeon-performed touch preparation of breast core needle biopsies may provide accurate same-day diagnosis and expedite treatment planning. / Gadgil, Pranjali V.; Korourian, Soheila; Malak, Sharp; Ochoa, Daniela; Lipschitz, Riley; Henry-Tillman, Ronda; Klimberg, Vicki.

In: Annals of Surgical Oncology, Vol. 21, No. 4, 2014, p. 1215-1221.

Research output: Contribution to journalArticle

Gadgil, Pranjali V. ; Korourian, Soheila ; Malak, Sharp ; Ochoa, Daniela ; Lipschitz, Riley ; Henry-Tillman, Ronda ; Klimberg, Vicki. / Surgeon-performed touch preparation of breast core needle biopsies may provide accurate same-day diagnosis and expedite treatment planning. In: Annals of Surgical Oncology. 2014 ; Vol. 21, No. 4. pp. 1215-1221.
@article{2ed687e92e5543c3acbbf2808648f479,
title = "Surgeon-performed touch preparation of breast core needle biopsies may provide accurate same-day diagnosis and expedite treatment planning",
abstract = "Background. We aimed to determine the accuracy of surgeon-performed touch-preparation cytology (TPC) of breast core-needle biopsies (CNB) and the ability to use TPC results to initiate treatment planning at the same patient visit. Methods. A single-institution retrospective review of TPC results of ultrasound-guided breast CNB was performed. All TPC slides were prepared by surgeons performing the biopsy and interpreted by the pathologist. TPC results were reported as positive/suspicious, atypical, negative/benign, or deferred; these were compared with final pathology of cores to calculate accuracy. Treatment planning was noted as having taken place if the patient had requisition of advanced imaging, referrals, or surgical planning undertaken during the same visit. Results. Four hundred forty-seven CNB specimens with corresponding TPC were evaluated from 434 patient visits, and 203 samples (45.4 {\%}) were malignant on final pathology. When the deferred, atypical, and benign results were considered negative and positive/suspicious results were considered positive, sensitivity and specificity were 83.7 {\%} (77.9-88.5 {\%}) and 98.4 {\%} (95.9-99.6 {\%}), respectively; positive and negative predictive values were 97.7 {\%} (94.2-99.4 {\%}) and 87.9 {\%} (83.4-91.5 {\%}), respectively. In practice, patients with atypical or deferred results were asked to await final pathology. An accurate same-day diagnosis (TPC positive/suspicious) was hence feasible in 83.7 {\%} (170 of 203) of malignant and 79.5 {\%} (194 of 244) of benign cases (TPC negative). Of patients who had a same-day diagnosis of a new malignancy, 77.3 {\%} had treatment planning initiated at the same visit. Conclusions. Surgeon-performed TPC of breast CNB is an accurate method of same-day diagnosis that allows treatment planning to be initiated at the same visit and may serve to expedite patient care.",
author = "Gadgil, {Pranjali V.} and Soheila Korourian and Sharp Malak and Daniela Ochoa and Riley Lipschitz and Ronda Henry-Tillman and Vicki Klimberg",
year = "2014",
doi = "10.1245/s10434-013-3440-5",
language = "English (US)",
volume = "21",
pages = "1215--1221",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Surgeon-performed touch preparation of breast core needle biopsies may provide accurate same-day diagnosis and expedite treatment planning

AU - Gadgil, Pranjali V.

AU - Korourian, Soheila

AU - Malak, Sharp

AU - Ochoa, Daniela

AU - Lipschitz, Riley

AU - Henry-Tillman, Ronda

AU - Klimberg, Vicki

PY - 2014

Y1 - 2014

N2 - Background. We aimed to determine the accuracy of surgeon-performed touch-preparation cytology (TPC) of breast core-needle biopsies (CNB) and the ability to use TPC results to initiate treatment planning at the same patient visit. Methods. A single-institution retrospective review of TPC results of ultrasound-guided breast CNB was performed. All TPC slides were prepared by surgeons performing the biopsy and interpreted by the pathologist. TPC results were reported as positive/suspicious, atypical, negative/benign, or deferred; these were compared with final pathology of cores to calculate accuracy. Treatment planning was noted as having taken place if the patient had requisition of advanced imaging, referrals, or surgical planning undertaken during the same visit. Results. Four hundred forty-seven CNB specimens with corresponding TPC were evaluated from 434 patient visits, and 203 samples (45.4 %) were malignant on final pathology. When the deferred, atypical, and benign results were considered negative and positive/suspicious results were considered positive, sensitivity and specificity were 83.7 % (77.9-88.5 %) and 98.4 % (95.9-99.6 %), respectively; positive and negative predictive values were 97.7 % (94.2-99.4 %) and 87.9 % (83.4-91.5 %), respectively. In practice, patients with atypical or deferred results were asked to await final pathology. An accurate same-day diagnosis (TPC positive/suspicious) was hence feasible in 83.7 % (170 of 203) of malignant and 79.5 % (194 of 244) of benign cases (TPC negative). Of patients who had a same-day diagnosis of a new malignancy, 77.3 % had treatment planning initiated at the same visit. Conclusions. Surgeon-performed TPC of breast CNB is an accurate method of same-day diagnosis that allows treatment planning to be initiated at the same visit and may serve to expedite patient care.

AB - Background. We aimed to determine the accuracy of surgeon-performed touch-preparation cytology (TPC) of breast core-needle biopsies (CNB) and the ability to use TPC results to initiate treatment planning at the same patient visit. Methods. A single-institution retrospective review of TPC results of ultrasound-guided breast CNB was performed. All TPC slides were prepared by surgeons performing the biopsy and interpreted by the pathologist. TPC results were reported as positive/suspicious, atypical, negative/benign, or deferred; these were compared with final pathology of cores to calculate accuracy. Treatment planning was noted as having taken place if the patient had requisition of advanced imaging, referrals, or surgical planning undertaken during the same visit. Results. Four hundred forty-seven CNB specimens with corresponding TPC were evaluated from 434 patient visits, and 203 samples (45.4 %) were malignant on final pathology. When the deferred, atypical, and benign results were considered negative and positive/suspicious results were considered positive, sensitivity and specificity were 83.7 % (77.9-88.5 %) and 98.4 % (95.9-99.6 %), respectively; positive and negative predictive values were 97.7 % (94.2-99.4 %) and 87.9 % (83.4-91.5 %), respectively. In practice, patients with atypical or deferred results were asked to await final pathology. An accurate same-day diagnosis (TPC positive/suspicious) was hence feasible in 83.7 % (170 of 203) of malignant and 79.5 % (194 of 244) of benign cases (TPC negative). Of patients who had a same-day diagnosis of a new malignancy, 77.3 % had treatment planning initiated at the same visit. Conclusions. Surgeon-performed TPC of breast CNB is an accurate method of same-day diagnosis that allows treatment planning to be initiated at the same visit and may serve to expedite patient care.

UR - http://www.scopus.com/inward/record.url?scp=84896086535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896086535&partnerID=8YFLogxK

U2 - 10.1245/s10434-013-3440-5

DO - 10.1245/s10434-013-3440-5

M3 - Article

VL - 21

SP - 1215

EP - 1221

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 4

ER -