Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research

Yosuke Niimi, Satoshi Fukuda, Ryan S. Gilbert, Tuvshintugs Baljinnyam, Yu Niimi, Hajime Matsumine, Keibun Liu, Sam Jacob, Hal K. Hawkins, Robert A. Cox, David N. Herndon, Donald Prough, Perenlei Enkhbaatar

Research output: Contribution to journalArticle

Abstract

The lack of a clinically relevant animal models for research in facial nerve reconstruction is challenging. In this study, we investigated the surgical anatomy of the ovine sural nerve as a potential candidate for facial nerve reconstruction, and performed its histological quantitative analysis in comparison to the buccal branch (BB) of the facial nerve using cadaver and anesthetized sheep. The ovine sural nerve descended to the lower leg along the short saphenous vein. The length of the sural nerve was 14.3 ± 0.5 cm. The distance from the posterior edge of the lateral malleolus to the sural nerve was 7.8 ± 1.8 mm. The mean number of myelinated fibers in the sural nerve was significantly lower than that of the BB (2,311 ± 381vs. 5,022 ± 433, respectively. p = 0.003). The number of fascicles in the sural nerve was also significantly lower than in the BB (10.5 ± 1.7 vs. 21.3 ± 2.7, respectively. p = 0.007). The sural nerve was grafted to the BB with end-to-end neurorrhaphy under surgical microscopy in cadaver sheep. The surgical anatomy and the number of fascicles of the ovine sural nerve were similar of those reported in humans. The results suggest that the sural nerve can be successfully used for facial nerve reconstruction research in a clinically relevant ovine model.

Original languageEnglish (US)
Article number10564
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Sural Nerve
Nerve Regeneration
Facial Nerve
Anatomy
Sheep
Cheek
Research
Cadaver
Saphenous Vein
Microscopy
Leg
Animal Models

ASJC Scopus subject areas

  • General

Cite this

Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research. / Niimi, Yosuke; Fukuda, Satoshi; Gilbert, Ryan S.; Baljinnyam, Tuvshintugs; Niimi, Yu; Matsumine, Hajime; Liu, Keibun; Jacob, Sam; Hawkins, Hal K.; Cox, Robert A.; Herndon, David N.; Prough, Donald; Enkhbaatar, Perenlei.

In: Scientific reports, Vol. 9, No. 1, 10564, 01.12.2019.

Research output: Contribution to journalArticle

Niimi, Y, Fukuda, S, Gilbert, RS, Baljinnyam, T, Niimi, Y, Matsumine, H, Liu, K, Jacob, S, Hawkins, HK, Cox, RA, Herndon, DN, Prough, D & Enkhbaatar, P 2019, 'Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research', Scientific reports, vol. 9, no. 1, 10564. https://doi.org/10.1038/s41598-019-46661-3
Niimi, Yosuke ; Fukuda, Satoshi ; Gilbert, Ryan S. ; Baljinnyam, Tuvshintugs ; Niimi, Yu ; Matsumine, Hajime ; Liu, Keibun ; Jacob, Sam ; Hawkins, Hal K. ; Cox, Robert A. ; Herndon, David N. ; Prough, Donald ; Enkhbaatar, Perenlei. / Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research. In: Scientific reports. 2019 ; Vol. 9, No. 1.
@article{3c9e97cdeed749f0bef44cb01760f4fc,
title = "Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research",
abstract = "The lack of a clinically relevant animal models for research in facial nerve reconstruction is challenging. In this study, we investigated the surgical anatomy of the ovine sural nerve as a potential candidate for facial nerve reconstruction, and performed its histological quantitative analysis in comparison to the buccal branch (BB) of the facial nerve using cadaver and anesthetized sheep. The ovine sural nerve descended to the lower leg along the short saphenous vein. The length of the sural nerve was 14.3 ± 0.5 cm. The distance from the posterior edge of the lateral malleolus to the sural nerve was 7.8 ± 1.8 mm. The mean number of myelinated fibers in the sural nerve was significantly lower than that of the BB (2,311 ± 381vs. 5,022 ± 433, respectively. p = 0.003). The number of fascicles in the sural nerve was also significantly lower than in the BB (10.5 ± 1.7 vs. 21.3 ± 2.7, respectively. p = 0.007). The sural nerve was grafted to the BB with end-to-end neurorrhaphy under surgical microscopy in cadaver sheep. The surgical anatomy and the number of fascicles of the ovine sural nerve were similar of those reported in humans. The results suggest that the sural nerve can be successfully used for facial nerve reconstruction research in a clinically relevant ovine model.",
author = "Yosuke Niimi and Satoshi Fukuda and Gilbert, {Ryan S.} and Tuvshintugs Baljinnyam and Yu Niimi and Hajime Matsumine and Keibun Liu and Sam Jacob and Hawkins, {Hal K.} and Cox, {Robert A.} and Herndon, {David N.} and Donald Prough and Perenlei Enkhbaatar",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-019-46661-3",
language = "English (US)",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research

AU - Niimi, Yosuke

AU - Fukuda, Satoshi

AU - Gilbert, Ryan S.

AU - Baljinnyam, Tuvshintugs

AU - Niimi, Yu

AU - Matsumine, Hajime

AU - Liu, Keibun

AU - Jacob, Sam

AU - Hawkins, Hal K.

AU - Cox, Robert A.

AU - Herndon, David N.

AU - Prough, Donald

AU - Enkhbaatar, Perenlei

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The lack of a clinically relevant animal models for research in facial nerve reconstruction is challenging. In this study, we investigated the surgical anatomy of the ovine sural nerve as a potential candidate for facial nerve reconstruction, and performed its histological quantitative analysis in comparison to the buccal branch (BB) of the facial nerve using cadaver and anesthetized sheep. The ovine sural nerve descended to the lower leg along the short saphenous vein. The length of the sural nerve was 14.3 ± 0.5 cm. The distance from the posterior edge of the lateral malleolus to the sural nerve was 7.8 ± 1.8 mm. The mean number of myelinated fibers in the sural nerve was significantly lower than that of the BB (2,311 ± 381vs. 5,022 ± 433, respectively. p = 0.003). The number of fascicles in the sural nerve was also significantly lower than in the BB (10.5 ± 1.7 vs. 21.3 ± 2.7, respectively. p = 0.007). The sural nerve was grafted to the BB with end-to-end neurorrhaphy under surgical microscopy in cadaver sheep. The surgical anatomy and the number of fascicles of the ovine sural nerve were similar of those reported in humans. The results suggest that the sural nerve can be successfully used for facial nerve reconstruction research in a clinically relevant ovine model.

AB - The lack of a clinically relevant animal models for research in facial nerve reconstruction is challenging. In this study, we investigated the surgical anatomy of the ovine sural nerve as a potential candidate for facial nerve reconstruction, and performed its histological quantitative analysis in comparison to the buccal branch (BB) of the facial nerve using cadaver and anesthetized sheep. The ovine sural nerve descended to the lower leg along the short saphenous vein. The length of the sural nerve was 14.3 ± 0.5 cm. The distance from the posterior edge of the lateral malleolus to the sural nerve was 7.8 ± 1.8 mm. The mean number of myelinated fibers in the sural nerve was significantly lower than that of the BB (2,311 ± 381vs. 5,022 ± 433, respectively. p = 0.003). The number of fascicles in the sural nerve was also significantly lower than in the BB (10.5 ± 1.7 vs. 21.3 ± 2.7, respectively. p = 0.007). The sural nerve was grafted to the BB with end-to-end neurorrhaphy under surgical microscopy in cadaver sheep. The surgical anatomy and the number of fascicles of the ovine sural nerve were similar of those reported in humans. The results suggest that the sural nerve can be successfully used for facial nerve reconstruction research in a clinically relevant ovine model.

UR - http://www.scopus.com/inward/record.url?scp=85070265500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070265500&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-46661-3

DO - 10.1038/s41598-019-46661-3

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 10564

ER -