Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer

Francesco Sopracordevole, Giuseppe Chiossi, Maggiorino Barbero, Paolo Cristoforoni, Bruno Ghiringhello, Antonio Frega, Francesca Tortolani, Fausto Boselli, Nicolò Clemente, Andrea Ciavattini, SOCIETY OF COLPOSCOPY ITALIAN SOCIETY OF COLPOSCOPY

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Aim: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). Patients and Methods: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). Results: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5±20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. Conclusion: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women.

Original languageEnglish (US)
Pages (from-to)4345-4350
Number of pages6
JournalAnticancer Research
Issue number8
StatePublished - Aug 1 2014
Externally publishedYes


  • Cone margins
  • Conization
  • Lymph vascular space invasion
  • Microinvasive cervical cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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