Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer

Francesco Sopracordevole, Giuseppe Chiossi, Maggiorino Barbero, Paolo Cristoforoni, Bruno Ghiringhello, Antonio Frega, Francesca Tortolani, Fausto Boselli, Nicolò Clemente, Andrea Ciavattini, SOCIETY OF COLPOSCOPY ITALIAN SOCIETY OF COLPOSCOPY

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). Patients and Methods: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). Results: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5±20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. Conclusion: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women.

Original languageEnglish (US)
Pages (from-to)4345-4350
Number of pages6
JournalAnticancer Research
Volume34
Issue number8
StatePublished - Aug 1 2014
Externally publishedYes

Fingerprint

Uterine Cervical Neoplasms
Lymph
Blood Vessels
Fertility Preservation
Conization
Neoplasms
Cohort Studies
Retrospective Studies
Safety
Recurrence
Mortality
Therapeutics

Keywords

  • Cone margins
  • Conization
  • Lymph vascular space invasion
  • Microinvasive cervical cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sopracordevole, F., Chiossi, G., Barbero, M., Cristoforoni, P., Ghiringhello, B., Frega, A., ... ITALIAN SOCIETY OF COLPOSCOPY, SOCIETY. OF. COLPOSCOPY. (2014). Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer. Anticancer Research, 34(8), 4345-4350.

Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer. / Sopracordevole, Francesco; Chiossi, Giuseppe; Barbero, Maggiorino; Cristoforoni, Paolo; Ghiringhello, Bruno; Frega, Antonio; Tortolani, Francesca; Boselli, Fausto; Clemente, Nicolò; Ciavattini, Andrea; ITALIAN SOCIETY OF COLPOSCOPY, SOCIETY OF COLPOSCOPY.

In: Anticancer Research, Vol. 34, No. 8, 01.08.2014, p. 4345-4350.

Research output: Contribution to journalArticle

Sopracordevole, F, Chiossi, G, Barbero, M, Cristoforoni, P, Ghiringhello, B, Frega, A, Tortolani, F, Boselli, F, Clemente, N, Ciavattini, A & ITALIAN SOCIETY OF COLPOSCOPY, SOCIETYOFCOLPOSCOPY 2014, 'Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer', Anticancer Research, vol. 34, no. 8, pp. 4345-4350.
Sopracordevole F, Chiossi G, Barbero M, Cristoforoni P, Ghiringhello B, Frega A et al. Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer. Anticancer Research. 2014 Aug 1;34(8):4345-4350.
Sopracordevole, Francesco ; Chiossi, Giuseppe ; Barbero, Maggiorino ; Cristoforoni, Paolo ; Ghiringhello, Bruno ; Frega, Antonio ; Tortolani, Francesca ; Boselli, Fausto ; Clemente, Nicolò ; Ciavattini, Andrea ; ITALIAN SOCIETY OF COLPOSCOPY, SOCIETY OF COLPOSCOPY. / Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer. In: Anticancer Research. 2014 ; Vol. 34, No. 8. pp. 4345-4350.
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