Surgical correction of severe vaginal introital stenosis in female babbons (Papio sp.) infected with simian agent 8

W. L. Singleton, C. B. Smikle, Gary Hankins, G. B. Hubbard, W. J. Ehler, K. B. Brasky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Simian agent 8 (SA8) is a neurotropic, endemic alphaherpesvirus in Papio sp. Lesions associated with simian agent 8 infections usually involve the genitalia of sexually mature baboons. In females, secondary bacterial infections may lead to scarring of the vulva and perineum, with resulting vaginal obstruction. Affected baboons are poor breeders and often develop urinary tract infections due to retention of urine in the vagina. Reconstructive vaginal surgery was performed on seven baboons with vaginal obstruction. Four weeks before surgery, 50 mg of Depo-Provera® was administered intramuscularly to each animal to arrest the estrous cycle, reduce swelling, and allow adequate surgical exposure of the vagina. Ventral and circular incisions were made around the constricted vagina. The peripheral skin was excised to break down the underlying connective tissue, allowing access to the vaginal mucosa. Healthy vaginal tissue was then opposed to the incised skin edges with 3-0 Vicryl in an interrupted pattern. Once healed, the vaginas remained patent, allowing normal mating and urination. Nine months after surgery, five baboons had healthy infants, and pregnancy was confirmed in the other two animals. The described procedure may allow female baboons previously infertile and at risk of urinary tract infections to be returned to a healthy reproductive state.

Original languageEnglish (US)
Pages (from-to)628-630
Number of pages3
JournalLaboratory Animal Science
Volume45
Issue number6
StatePublished - 1995
Externally publishedYes

Fingerprint

Cercopithecine herpesvirus 2
Papio
Surgery
Pathologic Constriction
vagina
Vagina
Skin
Animals
Tissue
urinary tract diseases
Polyglactin 910
Medroxyprogesterone Acetate
surgery
skin (animal)
Urinary Tract Infections
Swelling
Reconstructive Surgical Procedures
vaginal mucosa
perineum
urination

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Singleton, W. L., Smikle, C. B., Hankins, G., Hubbard, G. B., Ehler, W. J., & Brasky, K. B. (1995). Surgical correction of severe vaginal introital stenosis in female babbons (Papio sp.) infected with simian agent 8. Laboratory Animal Science, 45(6), 628-630.

Surgical correction of severe vaginal introital stenosis in female babbons (Papio sp.) infected with simian agent 8. / Singleton, W. L.; Smikle, C. B.; Hankins, Gary; Hubbard, G. B.; Ehler, W. J.; Brasky, K. B.

In: Laboratory Animal Science, Vol. 45, No. 6, 1995, p. 628-630.

Research output: Contribution to journalArticle

Singleton, WL, Smikle, CB, Hankins, G, Hubbard, GB, Ehler, WJ & Brasky, KB 1995, 'Surgical correction of severe vaginal introital stenosis in female babbons (Papio sp.) infected with simian agent 8', Laboratory Animal Science, vol. 45, no. 6, pp. 628-630.
Singleton, W. L. ; Smikle, C. B. ; Hankins, Gary ; Hubbard, G. B. ; Ehler, W. J. ; Brasky, K. B. / Surgical correction of severe vaginal introital stenosis in female babbons (Papio sp.) infected with simian agent 8. In: Laboratory Animal Science. 1995 ; Vol. 45, No. 6. pp. 628-630.
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