Surgical treatment of patients with Lennox-Gastaut syndrome phenotype

Shi Yong Liu, Ning An, Xiang Fang, Prabhdeep Singh, Joseph Oommen, Qing Yin, Mei Hua Yang, Yong Liu, Wei Liao, Chang Qing Gao, Hui Yang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Lennox-Gastaut syndrome (LGS) is a devastating and refractory generalized epilepsy affecting children and adolescents. In this study we report the results of resective surgery in 18 patients with LGS phenotype who underwent single-lobe/lesionectomy or multilobe resection plus multiple subpial transection and/or callosotomy. After surgery, seven patients became completely seizure-free (Engel Class I) and five almost seizure-free (Engel Class II). Additional four had significant seizure control (Engel Class III), and two had no change in seizure frequency (Engel Class IV). Of the 4 patients without any lesion on brain MRI, 2 ended with Engel Class II, 1 with III and the other with IV in Engels' classification. Mean intelligence quotient (IQ) increased from 56.1±8.1 (mean±SD) before operation to 67.4±8.2 (mean±SD) after operation, a significant improvement (P=0.001). Results also indicated that the younger the patient at surgery, or the shorter the interval between onset of seizure and resective operation, the better the intellectual outcome. Our data suggest that resective epilepsy surgery can be successful in patients with LGS phenotype as long as the EEG shows dominance of discharges in one hemisphere and corresponding ipsilateral imaging findings, even with contralateral ictal discharges.

Original languageEnglish (US)
Article number614263
JournalThe Scientific World Journal
StatePublished - 2012

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Environmental Science


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