Survival of a 75% burn in a patient with longstanding Addison's disease

S. E. James, S. J. Ghosh, J. Montgomerie, B. M. Philp, Peter Dziewulski

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This is the first reported case of survival of a significant burn in a patient with established Addison's disease. The systemic stress response to thermal injury is well recognised, there is a marked hypermetabolic response with prolonged periods of catabolism. In particular, the elevation of plasma cortisol levels is crucial for this response to severe systemic stress. Cortisol elevation is maintained for the duration of burn wound healing, is proportional to the burned body surface area and the normal circadian rhythm of endogenous cortisol is lost. Acute adrenal insufficiency has been described in patients suffering major burn injuries with generally poor outcomes. We discuss the management and complications of adrenal replacement therapy in a severe burn setting, as illustrated by this case report.

Original languageEnglish (US)
Pages (from-to)391-393
Number of pages3
JournalBurns
Volume28
Issue number4
DOIs
StatePublished - Jun 22 2002
Externally publishedYes

Fingerprint

Addison Disease
Hydrocortisone
Survival
Adrenal Insufficiency
Body Surface Area
Wounds and Injuries
Circadian Rhythm
Wound Healing
Hot Temperature
Therapeutics

Keywords

  • Addison's
  • Adrenal
  • Burn
  • Cortisol

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Survival of a 75% burn in a patient with longstanding Addison's disease. / James, S. E.; Ghosh, S. J.; Montgomerie, J.; Philp, B. M.; Dziewulski, Peter.

In: Burns, Vol. 28, No. 4, 22.06.2002, p. 391-393.

Research output: Contribution to journalArticle

James, S. E. ; Ghosh, S. J. ; Montgomerie, J. ; Philp, B. M. ; Dziewulski, Peter. / Survival of a 75% burn in a patient with longstanding Addison's disease. In: Burns. 2002 ; Vol. 28, No. 4. pp. 391-393.
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