TY - JOUR
T1 - Susceptibility of Ae. aegypti (Diptera
T2 - Culicidae) to infection with epidemic (subtype IC) and enzootic (subtypes ID, IIIC, HID) Venezuelan equine encephalitis complex alphaviruses
AU - Ortiz, Diana I.
AU - Kang, Wenli
AU - Weaver, Scott C.
PY - 2008/11
Y1 - 2008/11
N2 - To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.
AB - To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.
KW - Adaptation
KW - Alphavirus
KW - Mosquito
KW - Susceptibility
KW - Vector
KW - Venezuelan equine encephalitis
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U2 - 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2
DO - 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2
M3 - Article
C2 - 19058637
AN - SCOPUS:56749144296
VL - 45
SP - 1117
EP - 1125
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
SN - 0022-2585
IS - 6
ER -