Susceptibility of Ae. aegypti (Diptera

Culicidae) to infection with epidemic (subtype IC) and enzootic (subtypes ID, IIIC, HID) Venezuelan equine encephalitis complex alphaviruses

Diana I. Ortiz, Wenli Kang, Scott Weaver

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.

Original languageEnglish (US)
Pages (from-to)1117-1125
Number of pages9
JournalJournal of Medical Entomology
Volume45
Issue number6
DOIs
StatePublished - Nov 2008

Fingerprint

Venezuelan Equine Encephalomyelitides
Alphavirus
Peru
encephalitis
Culicidae
Diptera
horses
Infection
Venezuelan Equine Encephalitis Viruses
infection
Venezuela
Colombia
Dengue
dengue
viruses
dosage
testing

Keywords

  • Adaptation
  • Alphavirus
  • Mosquito
  • Susceptibility
  • Vector
  • Venezuelan equine encephalitis

ASJC Scopus subject areas

  • Insect Science
  • veterinary(all)
  • Infectious Diseases
  • Parasitology

Cite this

@article{c4d41a0879d2471794f6cfb2950285a0,
title = "Susceptibility of Ae. aegypti (Diptera: Culicidae) to infection with epidemic (subtype IC) and enzootic (subtypes ID, IIIC, HID) Venezuelan equine encephalitis complex alphaviruses",
abstract = "To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.",
keywords = "Adaptation, Alphavirus, Mosquito, Susceptibility, Vector, Venezuelan equine encephalitis",
author = "Ortiz, {Diana I.} and Wenli Kang and Scott Weaver",
year = "2008",
month = "11",
doi = "10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2",
language = "English (US)",
volume = "45",
pages = "1117--1125",
journal = "Journal of Medical Entomology",
issn = "0022-2585",
publisher = "Entomological Society of America",
number = "6",

}

TY - JOUR

T1 - Susceptibility of Ae. aegypti (Diptera

T2 - Culicidae) to infection with epidemic (subtype IC) and enzootic (subtypes ID, IIIC, HID) Venezuelan equine encephalitis complex alphaviruses

AU - Ortiz, Diana I.

AU - Kang, Wenli

AU - Weaver, Scott

PY - 2008/11

Y1 - 2008/11

N2 - To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.

AB - To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.

KW - Adaptation

KW - Alphavirus

KW - Mosquito

KW - Susceptibility

KW - Vector

KW - Venezuelan equine encephalitis

UR - http://www.scopus.com/inward/record.url?scp=56749144296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749144296&partnerID=8YFLogxK

U2 - 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2

DO - 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2

M3 - Article

VL - 45

SP - 1117

EP - 1125

JO - Journal of Medical Entomology

JF - Journal of Medical Entomology

SN - 0022-2585

IS - 6

ER -