Abstract
To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1117-1125 |
| Number of pages | 9 |
| Journal | Journal of Medical Entomology |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2008 |
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Keywords
- Adaptation
- Alphavirus
- Mosquito
- Susceptibility
- Vector
- Venezuelan equine encephalitis
ASJC Scopus subject areas
- Insect Science
- veterinary(all)
- Infectious Diseases
- Parasitology
Cite this
Susceptibility of Ae. aegypti (Diptera : Culicidae) to infection with epidemic (subtype IC) and enzootic (subtypes ID, IIIC, HID) Venezuelan equine encephalitis complex alphaviruses. / Ortiz, Diana I.; Kang, Wenli; Weaver, Scott.
In: Journal of Medical Entomology, Vol. 45, No. 6, 11.2008, p. 1117-1125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Susceptibility of Ae. aegypti (Diptera
T2 - Culicidae) to infection with epidemic (subtype IC) and enzootic (subtypes ID, IIIC, HID) Venezuelan equine encephalitis complex alphaviruses
AU - Ortiz, Diana I.
AU - Kang, Wenli
AU - Weaver, Scott
PY - 2008/11
Y1 - 2008/11
N2 - To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.
AB - To test the hypothesis that enzootic and epidemic Venezuelan equine encephalitis (VEE) complex alphaviruses can infect and be transmitted by Ae. aegypti, we conducted a series of experimental infection studies. One set of experiments tested the susceptibility of geographic strains of Ae. aegypti from Peru and Texas (USA) for epidemic (subtype IC) and enzootic (subtype ID) strains from Colombia/Venezuela, whereas the second set of experiments tested the susceptibility of Ae. aegypti from Iquitos, Peru, to enzootic VEE complex strains (subtypes ID, IIIC, and IIID) isolated in the same region, at different infectious doses. Experimental infections using artificial bloodmeals suggested that Ae. aegypti mosquitoes, particularly the strain from Iquitos, Peru, is moderately to highly susceptible to all of these VEE complex alphaviruses. The occurrence of enzootic VEE complex viruses circulating endemically in Iquitos suggests the possibility of a dengue-like transmission cycle among humans in tropical cities.
KW - Adaptation
KW - Alphavirus
KW - Mosquito
KW - Susceptibility
KW - Vector
KW - Venezuelan equine encephalitis
UR - http://www.scopus.com/inward/record.url?scp=56749144296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56749144296&partnerID=8YFLogxK
U2 - 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2
DO - 10.1603/0022-2585(2008)45[1117:SOAADC]2.0.CO;2
M3 - Article
VL - 45
SP - 1117
EP - 1125
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
SN - 0022-2585
IS - 6
ER -