Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

Satish K. Srivastava; J. Mark Petrash; Indira J. Sadana; Naseem H. Ansari; Catherine A. Partridge

doi:10.3109/02713688209000786

Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

Satish K. Srivastava, J. Mark Petrash, Indira J. Sadana, Naseem H. Ansari, Catherine A. Partridge

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Abstract

The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.

Original language	English (US)
Pages (from-to)	407-410
Number of pages	4
Journal	Current Eye Research
Volume	2
Issue number	6
DOIs	https://doi.org/10.3109/02713688209000786
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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title = "Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors",

abstract = "The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.",

author = "Srivastava, {Satish K.} and Petrash, {J. Mark} and Sadana, {Indira J.} and Ansari, {Naseem H.} and Partridge, {Catherine A.}",

note = "Funding Information: ACKNOWLEDGMENTS This investigation was supported by PHS grant EY 01677 awarded by the National Eye Institute, DHHS . We are grateful to Dr. M. J. Peterson, Pfizer Central Research, Groton, Connecticut for providing sorbinil, to Dr. s. D. Varma, University of Maryland, Baltimore, Maryland for providing quercitrin and Dr. Jin H. Kinoshita, National Eye Institute, Bethesda, Maryland for providing alrestatin.",

year = "1982",

doi = "10.3109/02713688209000786",

language = "English (US)",

volume = "2",

pages = "407--410",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Taylor and Francis Ltd.",

number = "6",

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TY - JOUR

T1 - Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

AU - Srivastava, Satish K.

AU - Petrash, J. Mark

AU - Sadana, Indira J.

AU - Ansari, Naseem H.

AU - Partridge, Catherine A.

N1 - Funding Information: ACKNOWLEDGMENTS This investigation was supported by PHS grant EY 01677 awarded by the National Eye Institute, DHHS . We are grateful to Dr. M. J. Peterson, Pfizer Central Research, Groton, Connecticut for providing sorbinil, to Dr. s. D. Varma, University of Maryland, Baltimore, Maryland for providing quercitrin and Dr. Jin H. Kinoshita, National Eye Institute, Bethesda, Maryland for providing alrestatin.

PY - 1982

Y1 - 1982

N2 - The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.

AB - The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.

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DO - 10.3109/02713688209000786

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JO - Current Eye Research

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ER -

Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

Abstract

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