Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

Satish K. Srivastava, J. Mark Petrash, Indira J. Sadana, Naseem H. Ansari, Catherine A. Partridge

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.

Original languageEnglish (US)
Pages (from-to)407-410
Number of pages4
JournalCurrent Eye Research
Volume2
Issue number6
DOIs
StatePublished - Jan 1 1982

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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