Susceptibility of Rickettsia rickettsii to Tigecycline in a Cell Culture Assay and Animal Model for Rocky Mountain Spotted Fever

Agriculture & Biology

• Rocky Mountain spotted fever 95%
• Rickettsia rickettsii 94%
• tigecycline 94%
• animal models 52%
• cell culture 47%
• doxycycline 35%
• assays 32%
• guinea pigs 10%
• quantitative polymerase chain reaction 10%
• minimum inhibitory concentration 6%
• ticks 6%
• vaccination 6%
• spleen 5%
• animals 5%
• testes 5%
• lungs 5%
• therapeutics 5%
• mouth 5%
• skin (animal) 5%
• liver 3%
• infection 3%
• tissues 2%
• cells 2%

Medicine & Life Sciences

• Rickettsia rickettsii 100%
• Rocky Mountain Spotted Fever 95%
• Tigecycline 82%
• Cell Culture Techniques 45%
• Animal Models 43%
• Doxycycline 30%
• Bacterial Load 23%
• Guinea Pigs 11%
• Tick-Borne Diseases 9%
• Vero Cells 8%
• Microbial Sensitivity Tests 7%
• Animals 6%
• Testis 5%
• Spleen 5%
• Polymerase Chain Reaction 3%
• Skin 3%
• Lung 3%
• Liver 3%
• Growth 3%
• In Vitro Techniques 2%
• Therapeutics 1%