Susceptibility of spiny rats (Proechimys semispinosus) to Leishmania (Viannia) panamensis and Leishmania (Leishmania) chagasi

Bruno Travi, L. T. Arteaga, A. P. Leon, G. H. Adler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The role of Proechimys semispinosus as reservoir of Leishmania (Viannia) panamensis on the Colombian Pacific coast was experimentally evaluated. The susceptibility to L. chagasi also was assessed to determine the utility of this rodent as a model for studying reservoir characteristics in the laboratory. Wild-caught animals were screened for natural tiypanosomatid infections, and negative individuals were inoculated intradermally (ID) in the snout or feet with 107 promastigotes of L. panamensis. L. chagasi was inoculated intracardially (107 promastigotes) or ID in the ear (108 promastigotes). PCR-hybridization showed that 15% of 33 spiny rats were naturally infected with L. Viannia sp. Animals experimentally infected with L. panamensis developed non-ulcerated lesions that disappeared by the 7th week post-infection (p.i.) and became more resistant upon reinfection. Infectivity to sand flies was low (I/ 20-1/48 infected/fed flies) and transient, and both culture and PCR-hybridization showed that L. panamensis was cleared by the 13th week p.i. Animals inoculated with L. chagasi became subclinically infected and were non-infective to sand flies. Transient infectivity to vectors of spiny rats infected with L. panamensis, combined with population characteristics, e.g., abundance, exploitation of degraded habitats and high reproductive rates, could make them epidemiologically suitable reservoirs.

Original languageEnglish (US)
Pages (from-to)887-892
Number of pages6
JournalMemorias do Instituto Oswaldo Cruz
Volume97
Issue number6
StatePublished - Sep 2002
Externally publishedYes

Fingerprint

Leishmania guyanensis
Leishmania infantum
Leishmania
Rats
Psychodidae
Animals
Sand
Infection
Polymerase Chain Reaction
Wild Animals
Population Characteristics
Diptera
Ecosystem
Ear
Coastal zones
Foot
Rodentia

Keywords

  • Experimental infection
  • Leishmania
  • Reservoir
  • Spiny rats

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Virology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Susceptibility of spiny rats (Proechimys semispinosus) to Leishmania (Viannia) panamensis and Leishmania (Leishmania) chagasi. / Travi, Bruno; Arteaga, L. T.; Leon, A. P.; Adler, G. H.

In: Memorias do Instituto Oswaldo Cruz, Vol. 97, No. 6, 09.2002, p. 887-892.

Research output: Contribution to journalArticle

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