Sustained release of herbal drugs using biodegradable scaffold for faster wound healing and better patient compliance

Arpan Biswas, Manori Amarajeewa, Sudipta Senapati, Manoranjan Sahu, Pralay Maiti

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Electrospun scaffold has been developed using biodegradable polymer and age old herbal drug for efficient wound healing patch with much better patient compliance. Positively charged smaller particle size (40 nm) of the drug has been prepared for greater penetration through epidermal barrier to enhance the wound healing activity of drug. Controlled drug release has been understood in terms of interactions between the components through spectroscopic techniques and calorimetric studies. In-vivo study using albino rats shows better wound healing efficiency of scaffold in terms of higher wound area contraction, minimum inflammation, faster epithelialization and vascularization. Cellular studies also endorse the scaffold as better biomaterial. Clinical studies also demonstrate fast healing of different type of wounds in presence of all three wound dressing materials with histological evidences. The complete biodegradation of the patch confirms its green nature of the developed patch.

Original languageEnglish (US)
Pages (from-to)2131-2141
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume14
Issue number7
DOIs
StatePublished - Oct 2018
Externally publishedYes

Keywords

  • Controlled release
  • Herbal drug
  • In-vivo and clinical studies
  • Wound dressing materials

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science

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