Sympathectomy induces novel purinergic sensitivity in sciatic afferents

Y. Chen, Y. H. Zhang, B. H. Bie, Z. Q. Zhao

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

AIM: To test the hypothesis that sympathectomy could induce novel purinergic sensitivity in sciatic afferents. METHODS: Teased-fiber recordings were made from 32 spontaneously active A afferents from the sciatic nerves in surgically sympathectomized rats and 30 spontaneously active A afferents from the sciatic nerves in intact rats. Adenosine 5'-triphosphate (ATP) was injected via a cannula in jugular vein. RESULTS: Twenty eight percent of the spontaneously active afferent fibers from sciatic nerves in the sympathectomized rats responded to ATP, either with an increase or with a decrease in spontaneous firing. However, none of the fibers from the sciatic nerves in the intact rats was activated by ATP. CONCLUSION: Sympathectomy induces novel purinergic sensitivity in A afferents from sciatic nerve.

Original languageEnglish (US)
Pages (from-to)1002-1004
Number of pages3
JournalActa Pharmacologica Sinica
Volume21
Issue number11
StatePublished - Dec 4 2000

Keywords

  • Adenosine triphosphate
  • Nerve fibers
  • Pain
  • Sympathectomy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Chen, Y., Zhang, Y. H., Bie, B. H., & Zhao, Z. Q. (2000). Sympathectomy induces novel purinergic sensitivity in sciatic afferents. Acta Pharmacologica Sinica, 21(11), 1002-1004.