Symptomatic hyperbilirubinemia secondary to dapsone-induced hemolysis and atazanavir therapy

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8 Scopus citations


The antiretroviral agent atazanavir is associated with mild asymptomatic hyperbilirubinemia. We report two cases of symptomatic hyperbilirubinemia attributed to atazanavir in conjunction with the Pneumocystis jirovecii pneumonia prophylaxis agent dapsone. Symptoms and laboratory evidence of hemolysis resolved upon discontinuation of dapsone, enabling successful antiretroviral therapy. Symptomatic hyperbilirubinemia due to hemolytic anemia is a potential adverse event when using the combination of atazanavir and dapsone in the treatment of patients with the human immunodeficiency virus.

Original languageEnglish (US)
Pages (from-to)1081-1083
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number2
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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