Symptoms of wheeze and persistent cough in the first year of life: Associations with indoor allergens, air contaminants, and maternal history of asthma

Kathleen Belanger, William Beckett, Elizabeth Triche, Michael B. Bracken, Theodore Holford, Ping Ren, Jean Ellen McSharry, Diane R. Gold, Thomas A E Platts-Mills, Brian P. Leaderer

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

In a cohort of 849 infants with an asthmatic sibling, the authors examined the relations of exposure to allergens (dust mite, cockroach, cat, and dog), nitrogen dioxide, and mold with symptoms of wheeze and persistent cough in the first year of life (1998-2000). Among infants whose mothers had physician-diagnosed asthma, neither dust mite allergen nor dog allergen was associated with either symptom. Exposure to cockroach allergen (Bla g 1 at ≥ 2 U/g) modestly increased the risk for wheeze (odds ratio (OR) = 1.87, 95% confidence interval (CI): 0.94, 3.71), and exposure to cat allergen modestly decreased the risk (OR = 0.60, 95% CI: 0.35, 1.03). Among infants of mothers with no asthma history, exposure to gas stoves (OR = 1.50, 95% CI: 1.05, 2.15) and wood-burning stoves (OR = 2.09, 95% CI: 1.12, 3.91) increased the risk of persistent cough. Similarly, measured nitrogen dioxide concentration was associated with persistent cough (OR = 1.21, 95% CI: 1.05, 1.40). Persistent mold affected both infants of mothers with asthma (for wheeze, OR = 2.27, 95% CI: 1.27, 4.07; for cough, OR = 1.83, 95% CI: 1.04, 3.22) and infants of mothers without asthma (for cough, OR = 1.55, 95% CI: 1.04, 2.31). Reported exposure was confirmed by an association of measured fungi with wheeze (OR = 1.23, 95% CI: 1.01, 1.49). This appears to have been the first study to measure all of these home exposures (indoor allergens, nitrogen dioxide, fungi) and to prospectively measure the frequency of infant wheeze and persistent cough.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalAmerican Journal of Epidemiology
Volume158
Issue number3
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Fingerprint

Cough
Allergens
Asthma
Odds Ratio
Air
Mothers
Confidence Intervals
Nitrogen Dioxide
Fungi
Cockroaches
Mites
Dust
Cats
Dogs
Siblings
Gases
Physicians

Keywords

  • Allergens
  • Cockroaches
  • Cough
  • Dust
  • Fungi
  • Infant
  • Nitrogen dioxide
  • Respiratory sounds

ASJC Scopus subject areas

  • Epidemiology

Cite this

Symptoms of wheeze and persistent cough in the first year of life : Associations with indoor allergens, air contaminants, and maternal history of asthma. / Belanger, Kathleen; Beckett, William; Triche, Elizabeth; Bracken, Michael B.; Holford, Theodore; Ren, Ping; McSharry, Jean Ellen; Gold, Diane R.; Platts-Mills, Thomas A E; Leaderer, Brian P.

In: American Journal of Epidemiology, Vol. 158, No. 3, 01.08.2003, p. 195-202.

Research output: Contribution to journalArticle

Belanger, K, Beckett, W, Triche, E, Bracken, MB, Holford, T, Ren, P, McSharry, JE, Gold, DR, Platts-Mills, TAE & Leaderer, BP 2003, 'Symptoms of wheeze and persistent cough in the first year of life: Associations with indoor allergens, air contaminants, and maternal history of asthma', American Journal of Epidemiology, vol. 158, no. 3, pp. 195-202. https://doi.org/10.1093/aje/kwg148
Belanger, Kathleen ; Beckett, William ; Triche, Elizabeth ; Bracken, Michael B. ; Holford, Theodore ; Ren, Ping ; McSharry, Jean Ellen ; Gold, Diane R. ; Platts-Mills, Thomas A E ; Leaderer, Brian P. / Symptoms of wheeze and persistent cough in the first year of life : Associations with indoor allergens, air contaminants, and maternal history of asthma. In: American Journal of Epidemiology. 2003 ; Vol. 158, No. 3. pp. 195-202.
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