Synaptic activity-regulated Wnt signaling in synaptic plasticity, glial function and chronic pain

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Wnt signaling pathways play important roles in various developmental and oncogenic processes. In the nervous system, Wnt signaling regulates neuronal morphogenesis and synaptic differentiation. Disturbance of Wnt signaling is implicated in the pathogenesis of neurological diseases. Recent studies indicate that Wnt signaling in neurons is closely coupled to synaptic activation, and that the activity-regulated Wnt signaling is critical for the expression of synaptic plasticity and the formation of memory. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain.

Original languageEnglish (US)
Pages (from-to)737-744
Number of pages8
JournalCNS and Neurological Disorders - Drug Targets
Volume13
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Neuronal Plasticity
Neuroglia
Chronic Pain
Nervous System
Neurons
Wnt Signaling Pathway
Morphogenesis

Keywords

  • Glia
  • Human immunodeficiency virus-1
  • Long-term potentiation
  • Mammalian target of rapamycin
  • N-methyl-D-aspartate
  • Neuroinflammation
  • Pain
  • Receptor
  • Synapse
  • Synaptic plasticity
  • Wnt

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

@article{67a320e92a664fc08aebefe9aa83a3a2,
title = "Synaptic activity-regulated Wnt signaling in synaptic plasticity, glial function and chronic pain",
abstract = "Wnt signaling pathways play important roles in various developmental and oncogenic processes. In the nervous system, Wnt signaling regulates neuronal morphogenesis and synaptic differentiation. Disturbance of Wnt signaling is implicated in the pathogenesis of neurological diseases. Recent studies indicate that Wnt signaling in neurons is closely coupled to synaptic activation, and that the activity-regulated Wnt signaling is critical for the expression of synaptic plasticity and the formation of memory. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain.",
keywords = "Glia, Human immunodeficiency virus-1, Long-term potentiation, Mammalian target of rapamycin, N-methyl-D-aspartate, Neuroinflammation, Pain, Receptor, Synapse, Synaptic plasticity, Wnt",
author = "Shao-Jun Tang",
year = "2014",
doi = "10.2174/1871527312666131223114457",
language = "English (US)",
volume = "13",
pages = "737--744",
journal = "CNS and Neurological Disorders - Drug Targets",
issn = "1871-5273",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Synaptic activity-regulated Wnt signaling in synaptic plasticity, glial function and chronic pain

AU - Tang, Shao-Jun

PY - 2014

Y1 - 2014

N2 - Wnt signaling pathways play important roles in various developmental and oncogenic processes. In the nervous system, Wnt signaling regulates neuronal morphogenesis and synaptic differentiation. Disturbance of Wnt signaling is implicated in the pathogenesis of neurological diseases. Recent studies indicate that Wnt signaling in neurons is closely coupled to synaptic activation, and that the activity-regulated Wnt signaling is critical for the expression of synaptic plasticity and the formation of memory. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain.

AB - Wnt signaling pathways play important roles in various developmental and oncogenic processes. In the nervous system, Wnt signaling regulates neuronal morphogenesis and synaptic differentiation. Disturbance of Wnt signaling is implicated in the pathogenesis of neurological diseases. Recent studies indicate that Wnt signaling in neurons is closely coupled to synaptic activation, and that the activity-regulated Wnt signaling is critical for the expression of synaptic plasticity and the formation of memory. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain.

KW - Glia

KW - Human immunodeficiency virus-1

KW - Long-term potentiation

KW - Mammalian target of rapamycin

KW - N-methyl-D-aspartate

KW - Neuroinflammation

KW - Pain

KW - Receptor

KW - Synapse

KW - Synaptic plasticity

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=84905588450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905588450&partnerID=8YFLogxK

U2 - 10.2174/1871527312666131223114457

DO - 10.2174/1871527312666131223114457

M3 - Article

C2 - 24365183

AN - SCOPUS:84905588450

VL - 13

SP - 737

EP - 744

JO - CNS and Neurological Disorders - Drug Targets

JF - CNS and Neurological Disorders - Drug Targets

SN - 1871-5273

IS - 5

ER -