Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma

Timothy Craig Allen, Cesar Moran

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma is rare. Cases from the archives of 2 large referral centers were reviewed to identify cases of synchronously occurring pulmonary carcinoma and pleural diffuse malignant mesothelioma. Three cases of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma were identified from more than 16000 pleuropulmonary cases and were reviewed for demographic, clinical, radiographic, histologic, and immurtohistochemical findings. The patients were men who were 63, 67, and 77 years old. Two had positive smoking histories; the smoking history of the other patient is unknown. One patient had a positive history of asbestos exposure; one patient had no history of asbestos exposure; and one patient's history of asbestos exposure is unknown. The patients underwent surgery for treatment of adenocarcinoma that was diagnosed preoperatively. Two of the adenocarcinomas were of a predominantly bronchioloalveolar pattern. No diffuse malignant mesothelioma was identified preoperatively. Diffuse malignant mesothelioma was suspected on the basis of pleural involvement by tumor with histology differing from that of the adenocarcinoma. Tumor immunostaining supported the diagnoses. The average survival after diagnosis was 6 weeks or less. In summary, the paucity of cases at 2 large referral centers and the paucity of cases reported in the English language literature highlights the rarity of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. These synchronous neoplasms occur in patients who have risk factors for both neoplasms independently. Length of survival following diagnosis is bleak.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number5
StatePublished - May 2006
Externally publishedYes

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Carcinoma
Lung
Asbestos
Adenocarcinoma
Multiple Primary Neoplasms
Referral and Consultation
Smoking
Neoplasms
Survival
Malignant Mesothelioma
Histology
Language
History
Demography
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. / Allen, Timothy Craig; Moran, Cesar.

In: Archives of Pathology and Laboratory Medicine, Vol. 130, No. 5, 05.2006, p. 721-724.

Research output: Contribution to journalReview article

Allen, Timothy Craig ; Moran, Cesar. / Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. In: Archives of Pathology and Laboratory Medicine. 2006 ; Vol. 130, No. 5. pp. 721-724.
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