Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes

Subhamoy Das, Anthony J. Monteforte, Gunjan Singh, Marjan Majid, Michael Sherman, Andrew K. Dunn, Aaron B. Baker

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.

    Original languageEnglish (US)
    JournalAdvanced healthcare materials
    DOIs
    StateAccepted/In press - 2016

    Fingerprint

    Syndecan-4
    Macrophages
    Medical problems
    Type 2 Diabetes Mellitus
    Blood
    Ischemia
    Extremities
    Fibroblast Growth Factor 2
    Polarization
    Tissue
    Immunomodulation
    Blood Vessels
    Therapeutics
    Perfusion
    Phenotype

    Keywords

    • Fibroblast growth factor-2 (FGF-2)
    • Ischemia
    • Peripheral vascular diseases
    • Syndecan-4
    • Therapeutic angiogenesis

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Biomaterials
    • Pharmaceutical Science

    Cite this

    Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes. / Das, Subhamoy; Monteforte, Anthony J.; Singh, Gunjan; Majid, Marjan; Sherman, Michael; Dunn, Andrew K.; Baker, Aaron B.

    In: Advanced healthcare materials, 2016.

    Research output: Contribution to journalArticle

    Das, Subhamoy ; Monteforte, Anthony J. ; Singh, Gunjan ; Majid, Marjan ; Sherman, Michael ; Dunn, Andrew K. ; Baker, Aaron B. / Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes. In: Advanced healthcare materials. 2016.
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    AU - Sherman, Michael

    AU - Dunn, Andrew K.

    AU - Baker, Aaron B.

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