Syndrome of androgen insensitivity in man: absence of 5α dihydrotestosterone binding protein in skin fibroblasts

B. S. Keenan, Walter Meyer, A. J. Hadjian, H. W. Jones, C. J. Migeon

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

A method was developed for measuring specific dihydrotestosterone (DHT) binding in cultured human skin fibroblasts. Initial studies indicate that about one half of the measured binding is nuclear and the rest cytoplasmic. The amount of binding per cell and the dissociation constant measured in normal fibroblasts is comparable to reported values for prostatic tissue. No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein (s) could account for the syndrome of androgen insensitivity (testicular feminization) in man.

Original languageEnglish (US)
Pages (from-to)1143-1146
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number6
StatePublished - 1974
Externally publishedYes

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Androgen-Insensitivity Syndrome
Dihydrotestosterone
Fibroblasts
Androgens
Skin
Carrier Proteins
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Syndrome of androgen insensitivity in man : absence of 5α dihydrotestosterone binding protein in skin fibroblasts. / Keenan, B. S.; Meyer, Walter; Hadjian, A. J.; Jones, H. W.; Migeon, C. J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 38, No. 6, 1974, p. 1143-1146.

Research output: Contribution to journalArticle

Keenan, B. S. ; Meyer, Walter ; Hadjian, A. J. ; Jones, H. W. ; Migeon, C. J. / Syndrome of androgen insensitivity in man : absence of 5α dihydrotestosterone binding protein in skin fibroblasts. In: Journal of Clinical Endocrinology and Metabolism. 1974 ; Vol. 38, No. 6. pp. 1143-1146.
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