Syndrome of androgen insensitivity in man: Absence of 5 α - dihydrotestosterone binding protein in skin fibroblasts

Bruce S. Keenan, Walter J. Meyer, Arthur J. Hadjian, Howard W. Jones, Claude J. Migeon

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

A method has been developed for measuring specific DHT binding in cultured human skin fibroblasts. Initial studies indicate that about one half of the measured bindingis nuclear and the rest cytoplasmic. The amount of binding per cell and the dissociation constant measured in normal fibroblasts is comparable to reported values for prostatic tissue. No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein (s) could account for the syndrome of androgen insensitivity (testicular feminization) in man.

Original languageEnglish (US)
Pages (from-to)1143-1146
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number6
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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