Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R. K.Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala Devi Kanneganti

Research output: Contribution to journalArticlepeer-review

780 Scopus citations

Abstract

TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

Original languageEnglish (US)
Pages (from-to)149-168.e17
JournalCell
Volume184
Issue number1
DOIs
StatePublished - Jan 7 2021
Externally publishedYes

Keywords

  • COVID-19
  • IFN-γ
  • PANoptosis
  • SARS-CoV-2
  • TNF-α
  • apoptosis
  • cytokine storm
  • inflammation
  • necroptosis
  • pyroptosis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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