Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

  • Rajendra Karki
  • , Bhesh Raj Sharma
  • , Shraddha Tuladhar
  • , Evan Peter Williams
  • , Lillian Zalduondo
  • , Parimal Samir
  • , Min Zheng
  • , Balamurugan Sundaram
  • , Balaji Banoth
  • , R. K.Subbarao Malireddi
  • , Patrick Schreiner
  • , Geoffrey Neale
  • , Peter Vogel
  • , Richard Webby
  • , Colleen Beth Jonsson
  • , Thirumala Devi Kanneganti

Research output: Contribution to journalArticlepeer-review

1363 Scopus citations

Abstract

TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

Original languageEnglish (US)
Pages (from-to)149-168.e17
JournalCell
Volume184
Issue number1
DOIs
StatePublished - Jan 7 2021
Externally publishedYes

Keywords

  • COVID-19
  • IFN-γ
  • PANoptosis
  • SARS-CoV-2
  • TNF-α
  • apoptosis
  • cytokine storm
  • inflammation
  • necroptosis
  • pyroptosis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes'. Together they form a unique fingerprint.

Cite this