Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki; Bhesh Raj Sharma; Shraddha Tuladhar; Evan Peter Williams; Lillian Zalduondo; Parimal Samir; Min Zheng; Balamurugan Sundaram; Balaji Banoth; R. K.Subbarao Malireddi; Patrick Schreiner; Geoffrey Neale; Peter Vogel; Richard Webby; Colleen Beth Jonsson; Thirumala Devi Kanneganti

doi:10.1016/j.cell.2020.11.025

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki
, Bhesh Raj Sharma
, Shraddha Tuladhar
, Evan Peter Williams
, Lillian Zalduondo
, Parimal Samir
, Min Zheng
, Balamurugan Sundaram
, Balaji Banoth
, R. K.Subbarao Malireddi
, Patrick Schreiner
, Geoffrey Neale
, Peter Vogel
, Richard Webby
, Colleen Beth Jonsson
, Thirumala Devi Kanneganti

Research output: Contribution to journal › Article › peer-review

1490 Scopus citations

Abstract

TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

Original language	English (US)
Pages (from-to)	149-168.e17
Journal	Cell
Volume	184
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2020.11.025
State	Published - Jan 7 2021
Externally published	Yes

Keywords

COVID-19
IFN-γ
PANoptosis
SARS-CoV-2
TNF-α
apoptosis
cytokine storm
inflammation
necroptosis
pyroptosis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2020.11.025

Cite this

Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., Schreiner, P., Neale, G., Vogel, P., Webby, R., Jonsson, C. B., & Kanneganti, T. D. (2021). Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell, 184(1), 149-168.e17. https://doi.org/10.1016/j.cell.2020.11.025

Karki, R, Sharma, BR, Tuladhar, S, Williams, EP, Zalduondo, L, Samir, P, Zheng, M, Sundaram, B, Banoth, B, Malireddi, RKS, Schreiner, P, Neale, G, Vogel, P, Webby, R, Jonsson, CB & Kanneganti, TD 2021, 'Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes', Cell, vol. 184, no. 1, pp. 149-168.e17. https://doi.org/10.1016/j.cell.2020.11.025

@article{95e17ce14f9541b2914a09604e8fe4c8,

title = "Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes",

abstract = "TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.",

keywords = "COVID-19, IFN-γ, PANoptosis, SARS-CoV-2, TNF-α, apoptosis, cytokine storm, inflammation, necroptosis, pyroptosis",

author = "Rajendra Karki and Sharma, \{Bhesh Raj\} and Shraddha Tuladhar and Williams, \{Evan Peter\} and Lillian Zalduondo and Parimal Samir and Min Zheng and Balamurugan Sundaram and Balaji Banoth and Malireddi, \{R. K.Subbarao\} and Patrick Schreiner and Geoffrey Neale and Peter Vogel and Richard Webby and Jonsson, \{Colleen Beth\} and Kanneganti, \{Thirumala Devi\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jan,

day = "7",

doi = "10.1016/j.cell.2020.11.025",

language = "English (US)",

volume = "184",

pages = "149--168.e17",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

AU - Karki, Rajendra

AU - Sharma, Bhesh Raj

AU - Tuladhar, Shraddha

AU - Williams, Evan Peter

AU - Zalduondo, Lillian

AU - Samir, Parimal

AU - Zheng, Min

AU - Sundaram, Balamurugan

AU - Banoth, Balaji

AU - Malireddi, R. K.Subbarao

AU - Schreiner, Patrick

AU - Neale, Geoffrey

AU - Vogel, Peter

AU - Webby, Richard

AU - Jonsson, Colleen Beth

AU - Kanneganti, Thirumala Devi

PY - 2021/1/7

Y1 - 2021/1/7

N2 - TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

AB - TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

KW - COVID-19

KW - IFN-γ

KW - PANoptosis

KW - SARS-CoV-2

KW - TNF-α

KW - apoptosis

KW - cytokine storm

KW - inflammation

KW - necroptosis

KW - pyroptosis

UR - https://www.scopus.com/pages/publications/85096507789

UR - https://www.scopus.com/pages/publications/85096507789#tab=citedBy

U2 - 10.1016/j.cell.2020.11.025

DO - 10.1016/j.cell.2020.11.025

M3 - Article

C2 - 33278357

AN - SCOPUS:85096507789

SN - 0092-8674

VL - 184

SP - 149-168.e17

JO - Cell

JF - Cell

IS - 1

ER -

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this