Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.
|Original language||English (US)|
|Number of pages||4|
|Journal||Archives of Environmental Contamination and Toxicology|
|State||Published - Jul 1 1988|
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis