Synergistic inactivation of plasma α1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane

G. A.S. Ansari, Jose C. Gan, Brian K. Barton

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.

Original languageEnglish (US)
Pages (from-to)533-536
Number of pages4
JournalArchives of Environmental Contamination and Toxicology
Volume17
Issue number4
DOIs
StatePublished - Jul 1 1988

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ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

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