Synergistic inactivation of plasma α1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane

Ghulam Ansari, Jose C. Gan, Brian K. Barton

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.

Original languageEnglish (US)
Pages (from-to)533-536
Number of pages4
JournalArchives of Environmental Contamination and Toxicology
Volume17
Issue number4
DOIs
StatePublished - Jul 1988

Fingerprint

styrene oxide
aldehyde
Aldehydes
Smoke
Tobacco Products
smoke
Styrene
inhibitor
Peptide Hydrolases
oxide
Pyruvaldehyde
Acrolein
Industrial chemicals
Plasmas
Chemical Industry
plasma
Oxides
Emphysema
Lung
Industry

ASJC Scopus subject areas

  • Toxicology
  • Environmental Chemistry
  • Environmental Science(all)

Cite this

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abstract = "Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.",
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AU - Barton, Brian K.

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AB - Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.

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