Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome

Paul J. Boor, M Khan, Bhupendra Kaphalia, Thomas R. Jerrells, Ghulam Ansari

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The underlying etiology of the toxic oil syndrome may be related to any of several toxic contaminants. The hypothesis is made that two or more toxic compounds may act synergistically to cause vascular damage in the toxic oil syndrome. To support this hypothesis, previous studies are reviewed concerning the remarkable synergistic toxic action of allylamine and beta-aminopropionitrile on the media of blood vessels. Although these toxins are not directly related to the toxic oil syndrome, this previous experimental work emphasizes the possibility that unexplored synergistic actions may be important. Furthermore, the hypothesis that contaminating fatty acid anilides in toxic oil undergo alterations during cooking is supported by high pressure liquid chromatographic analysis. The theoretic metabolism of fatty acid anilides is discussed. Recent data concerning the toxic actions of the anilides of oleic and linoleic acid are given. These data suggest that these anilides induce immunologic alterations that may be similar to those seen in the toxic oil syndrome. In addition, the heated anilides appear to have increased toxicity, supporting the concept that the use of toxic oil in cooking may increase its toxicity.

Original languageEnglish (US)
Pages (from-to)1824-1828
Number of pages5
JournalJournal of the American College of Cardiology
Volume18
Issue number7
DOIs
StatePublished - 1991

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Anilides
Poisons
Blood Vessels
Oils
Fatty Acids
Toxic Actions
Cooking
Aminopropionitrile
Allylamine
Linoleic Acid
Oleic Acid
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Nursing(all)

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Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome. / Boor, Paul J.; Khan, M; Kaphalia, Bhupendra; Jerrells, Thomas R.; Ansari, Ghulam.

In: Journal of the American College of Cardiology, Vol. 18, No. 7, 1991, p. 1824-1828.

Research output: Contribution to journalArticle

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